{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:52:00Z","timestamp":1791287520918,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["2014\/122"],"award-info":[{"award-number":["2014\/122"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["2011\/196"],"award-info":[{"award-number":["2011\/196"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["20111204169"],"award-info":[{"award-number":["20111204169"]}],"id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence of all known human herpesviruses (HHV) in tonsils of an age\u2010stratified large sample of immunocompetent children and adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing tonsillectomy for benign indications were recruited in 19 French hospitals. After resection, the entire outer surfaces of right and left half tonsils were extensively brushed. A highly sensitive species\u2010specific multiplex assay was used to detect herpes simplex virus 1 (HSV1), HSV2, Epstein\u2010Barr virus (EBV; types 1 and 2), and human cytomegalovirus (CMV) DNA in 688, as well as varicella zoster virus (VZV), HHV6A, HHV6B, HHV7, and Kaposi's sarcoma\u2010associated herpesvirus (KSHV) DNA in a subset of 440 tonsil brushings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall 85% of tonsil brushing samples were infected with at least one HHV species. HHV7 and EBV were the most prevalent (\u224870%), followed by HHV6B (\u224850%), HSV1, CMV, VZV (\u22482%), and KSHV and HSV2 (&lt;1%), while HHV6A was not detected. EBV prevalence was significantly higher in adults than in children, whereas it was opposite for HHV6B and VZV. No difference in HHV prevalence was observed by sex. In multivariate analysis, EBV detection was associated with age greater than or equal to 15 years (prevalence ratio [PR]\u2009=\u20091.8; 95% confidence interval [CI]: 1.5\u20102.3) and marginally with tobacco smoking (PR\u2009=\u20091.2; 95% CI: 1.1\u20101.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Differing patterns of HHV infection in tonsils in a large age\u2010stratified population were described. This study is by far the largest available and shows that EBV, HHV6B, and HHV7 are commonly detected in the tonsils in both men and women, in contrast to other HHVs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.25338","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T01:34:32Z","timestamp":1539567272000},"page":"687-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study"],"prefix":"10.1002","volume":"91","author":[{"given":"Aboud","family":"Kourieh","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Gheit","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Tommasino","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Dalstein","sequence":"additional","affiliation":[{"name":"CHU Reims, H\u00f4pital Maison Blanche, Laboratoire Biopathologie Reims France"},{"name":"INSERM, UMR\u2010S 1250, Universit\u00e9 de Reims Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Clifford","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Lacau St Guily","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Faculty of Medicine, Sorbonne University and Tenon Hospital, Assistance Publique H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Clavel","sequence":"additional","affiliation":[{"name":"CHU Reims, H\u00f4pital Maison Blanche, Laboratoire Biopathologie Reims France"},{"name":"INSERM, UMR\u2010S 1250, Universit\u00e9 de Reims Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Aviano National Cancer Institute Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-1086","authenticated-orcid":false,"given":"Jean\u2010Damien","family":"Combes","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the SPLIT study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_9_1_2_1","unstructured":"International Committee on Taxonomy of Virus. 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