{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:12:45Z","timestamp":1775272365028,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009060","name":"Sidaction","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Infection with hepatitis B virus (HBV) genotype G has been associated with increased liver fibrosis levels compared with other genotypes in cross\u2010sectional studies, yet its role in fibrosis evolution remains to be established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 158 human immunodeficiency virus (HIV)\u2010HBV coinfected patients had available HBV genotyping at baseline. Liver fibrosis was assessed at baseline and every 6 to 12 months by the FibroTest (BioPredictive, Paris, France). Risk factors for fibrosis regression (F3\u2010F4 to F0\u2010F1\u2010F2) and progression (F0\u2010F1\u2010F2 to F3\u2010F4) between baseline and end of follow\u2010up were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most patients were male (88.6%) with a\u00a0median age of 39 years. HBV genotype A was more prevalent compared with other HBV genotypes (62.7% vs D\u2009=\u200910.8%, E\u2009=\u200910.8%, and G\u2009=\u200915.8%). Patients were followed up for a median of 83 months (IQR\u2009=\u200937\u201097). In the 43 (27.2%) patients with F3\u2010F4 baseline liver fibrosis, 7 (16.2%) regressed to F0\u2010F1\u2010F2 fibrosis at the last follow\u2010up visit. In the 115 (72.8%) with F0\u2010F1\u2010F2 fibrosis at baseline, 19 (16.5%) progressed to F3\u2010F4 fibrosis at last visit. In multivariable analysis, fibrosis progression was independently associated with older age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;0.005), baseline CD4+ cell count less than 350\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;0.01), longer antiretroviral therapy duration (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;0.03), and HBV genotype G infection (vs non\u2010G,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;0.01). When examining averages over time, the rate of FibroTest increase was faster in genotype G vs non\u2010G\u2013infected patients with baseline F0\u2010F1\u2010F2 fibrosis (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction\u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In HIV\u2010HBV coinfected patients, HBV genotype G is an independent risk factor for liver fibrosis progression as determined by noninvasive markers. HBV genotype G\u2013infected patients with low initial liver fibrosis levels may require more careful monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.25360","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T18:20:43Z","timestamp":1542306043000},"page":"630-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hepatitis B virus genotype G and liver fibrosis progression in chronic hepatitis B and human immunodeficiency virus coinfection"],"prefix":"10.1002","volume":"91","author":[{"given":"Vincenzo","family":"Malagnino","sequence":"first","affiliation":[{"name":"Department of System Medicine Clinical of Infectious Diseases, Tor Vergata University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Bottero","sequence":"additional","affiliation":[{"name":"Unite de Maladies Infectieuses et Tropicales, CHU 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