{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:54:38Z","timestamp":1764402878914,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Direct acting antiviral has offered treatment of hepatitis C virus (HCV) recurrence post liver transplantation (LT) with an all\u2010oral regimen for short duration, excellent safety profile, and high sustained virological response (SVR). The aim of this study was to evaluate the efficacy and safety of sofosbuvir (SOF)\u2010based regimens in the real world among a cohort of Egyptian patients with recurrent HCV post living donor LT (LDLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HCV\u2010G4 recurrence post\u2010LDLT were recruited from National Committee of Control of Viral Hepatitis, Egypt, from November 2014 to May 2017. They received different SOF\u2010based regimens according to the treatment protocols available during this period. Patients\u2019 outcome and Adverse effects (AE) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred ninety patients (170 males, mean age 56.8\u2009\u00b1\u20097.9 years) were included. Calcineurin inhibitors were the main immunosuppression used (173 patients). Out of 190, 119 (62.6%) received SOF\/ribavirin (RBV), 38 (20%) SOF\/simeprevir (SMV), 22 (11.6%) SOF\/daclatasvir (DSV)\/\u2009\u00b1\u2009RBV, and 11 (5.8%) received SOF\/LDV\/\u2009\u00b1\u2009RBV. Overall SVR12 was 89.5%, 84.9% in SOF\/RBV group, 94.7% in SOF\/SMV, 100% in SOF\/DCV, and 100% in SOF\/LDV with no statistically significant difference (\n<jats:italic>P<\/jats:italic>\u2009=\u20090.104). The AE reported were as follows: anemia (n\u2009=\u200965, 34.4%) mainly in SOF\/RBV group, transient hyperbilirubinemia during SOF\/SMV in 13 patients (34%), mild Acute cellular rejection in eight patients (4.2%), and hepatocellular carcinoma in two patients (1%) mainly driven by underlying liver condition. Two deaths were unlikely related to HCV therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Different SOF\u2010based regimens were effective with high SVR12 rates in a difficult\u2010to\u2010treat population, recurrent HCV post LDLT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25362","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T10:13:52Z","timestamp":1544782432000},"page":"668-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ef\ufb01cacy and safety of sofosbuvir\u2010based therapy in hepatitis C virus recurrence post living donor liver transplant: A real life egyptian experience"],"prefix":"10.1002","volume":"91","author":[{"given":"Ayman","family":"Yosry","sequence":"first","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9058-9888","authenticated-orcid":false,"given":"Hadeel","family":"Gamal Eldeen","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Medhat","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7934-891X","authenticated-orcid":false,"given":"Mai","family":"Mehrez","sequence":"additional","affiliation":[{"name":"National Hepatology and Tropical Medicine Research Institute Cairo Governorate Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa","family":"Zayed","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafaa","family":"Elakel","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham","family":"Abdelmoniem","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Kaddah","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal","family":"Esmat","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdy","family":"EL\u2010Serafy","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wahid","family":"Doss","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Faculty of Medicine, Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"e_1_2_15_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2014.04.003"},{"key":"e_1_2_15_1_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i4.1650"},{"key":"e_1_2_15_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24416"},{"key":"e_1_2_15_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20857"},{"key":"e_1_2_15_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"e_1_2_15_1_7_1","first-page":"652","article-title":"Chances and limitations of non\u2010invasive tests in the assessment of liver \ufb01brosis in liver transplant patients","volume":"24","author":"Kamphues C","year":"2010","journal-title":"ClinTransplant"},{"key":"e_1_2_15_1_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.001"},{"key":"e_1_2_15_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27681"},{"key":"e_1_2_15_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13923"},{"key":"e_1_2_15_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000531"},{"key":"e_1_2_15_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12634"},{"key":"e_1_2_15_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27770"},{"key":"e_1_2_15_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12856"},{"key":"e_1_2_15_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61036-9"},{"key":"e_1_2_15_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28446"},{"key":"e_1_2_15_1_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.010"},{"key":"e_1_2_15_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13390"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:52:53Z","timestamp":1694332373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,14]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/jmv.25362"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25362","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2018,12,14]]},"assertion":[{"value":"2018-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}