{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:28:34Z","timestamp":1762295314797,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Ocular herpes, caused by herpes simplex virus type 1 (HSV\u20101) and type 2 (HSV\u20102) infections, remains an important corneal disease, which may result in loss of vision. Because the frequency of acyclovir resistance in HSV has increased, novel antiviral agents are needed for therapeutic approaches to ocular herpes. Several studies have demonstrated that fusion proteins containing entire ectodomain of HSV glycoprotein D receptors, including herpesvirus entry mediator A (HVEM), nectin\u20101 and nectin\u20102, and the Fc portion of human IgG (HVEMIg, nectin\u20101Ig, and nectin\u20102Ig, respectively), can exert antiviral effects in vitro and in vivo. Here, to evaluate the antiviral potential of HVEMIg, nectin\u20101Ig, and nectin\u20102Ig against ocular infections with HSV, transgenic mice expressing these fusion proteins were ocularly inoculated with HSV\u20101 and HSV\u20102. Transgenic mouse lines expressing HVEMIg and nectin\u20101Ig showed marked resistance to ocular herpes; on the other hand, mouse lines expressing nectin\u20102Ig did not. Furthermore, to investigate the therapeutic effects of nectin\u20101Ig, which can neutralize HSVs in vitro against ocular disease, transgenic mouse serum containing nectin\u20101Ig was dropped into the eyes of wild\u2010type mice after HSV infection. Reduction of severe symptoms could be observed in mice treated with nectin\u20101Ig serum. These results warrant further study of soluble HVEM and nectin\u20101 products as preventive and therapeutic agents against ocular herpes caused by HSV\u20101 and HSV\u20102 infections, especially nectin\u20101Ig as a new eye drop.<\/jats:p>","DOI":"10.1002\/jmv.25384","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T22:04:30Z","timestamp":1545429870000},"page":"820-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the antiviral potential of the soluble forms of glycoprotein D receptors on ocular herpes caused by HSV\u20101 and HSV\u20102 infections in a transgenic mouse model"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-3291","authenticated-orcid":false,"given":"Yoshikazu","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Biomedicine Graduate School of Medical Sciences, Kyushu University 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