{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:34:36Z","timestamp":1781627676068,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017\u201005807"],"award-info":[{"award-number":["2017\u201005807"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (<jats:italic>Rattus norvegicus<\/jats:italic>), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belgium, and human cases of SEOV infection have been reported in Germany, UK, France, and Belgium. In the search of hantaviruses in brown rats from the Netherlands, we found both serological and genetic evidence for the presence of SEOV in the local wild rat population. To further decipher the relationship with other SEOV variants globally, the complete genome of SEOV in the Netherlands was recovered. SEOV sequences obtained from three positive rats (captured at close trapping locations at the same time) were found highly similar. Phylogenetic analyses demonstrated that two lineages of SEOV circulate in Europe. Strains from the Netherlands and UK, together with the Baxter strain from US, constitute one of these two, while the second includes strains from Europe and Asia. Our results support a hypothesis of diverse routes of SEOV spread into Europe. These findings, combined with other indications on the expansion of the spatial European range of SEOV, suggest an increased risk of this virus for the public health, highlighting the need for increased surveillance.<\/jats:p>","DOI":"10.1002\/jmv.25390","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T19:02:31Z","timestamp":1546628551000},"page":"724-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Genetic analyses of Seoul hantavirus genome recovered from rats (<i>Rattus norvegicus<\/i>) in the Netherlands unveils diverse routes of spread into Europe"],"prefix":"10.1002","volume":"91","author":[{"given":"Jiaxin","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology Zoonosis Science Center, University of Uppsala Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Verner\u2010Carlsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology Zoonosis Science Center, University of Uppsala Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-403X","authenticated-orcid":false,"given":"Per","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology Zoonosis Science Center, University of Uppsala Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Plyusnina","sequence":"additional","affiliation":[{"name":"Department of Virology Medicum, University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mare","family":"L\u00f6hmus","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology Zoonosis Science Center, University of Uppsala Uppsala Sweden"},{"name":"Institute for Environmental Medicine, Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Occupational and Environmental Medicine, Stockholm County Council Stockholm Sweden"},{"name":"The National Veterinary Institute Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef D.","family":"J\u00e4rhult","sequence":"additional","affiliation":[{"name":"Section for Infectious Diseases, Department of Medical Sciences Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van de Goot","sequence":"additional","affiliation":[{"name":"Symbiant Pathology Expert Centre Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Plyusnin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology Zoonosis Science Center, University of Uppsala Uppsala Sweden"},{"name":"Department of Virology Medicum, University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-6551","authenticated-orcid":false,"given":"\u00c5ke","family":"Lundkvist","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology Zoonosis Science Center, University of Uppsala Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Sironen","sequence":"additional","affiliation":[{"name":"Department of Virology Medicum, University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_6_1_2_1","unstructured":"Group. 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