{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:05:18Z","timestamp":1781827518152,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Varicella\u2010zoster virus (VZV)\u2010specific cell\u2010mediated immunity (CMI) is critical for preventing and controlling the onset of herpes zoster (HZ). To assess VZV CMI, an interferon\u2010\u03b3 (IFN\u2010\u03b3) enzyme\u2010linked immunosorbent assay (ELISA) was validated by examining the influence of VZV\u2010specific antigen content, incubation time, and interval from whole blood collection on the assay. In phase II clinical trial, VZV\u2010specific CMI in adults \u226550 years of age administered an HZ vaccine were evaluated by IFN\u2010\u03b3 ELISA, as determined by measuring IFN\u2010\u03b3 production in the whole blood in response to stimulation with ultraviolet light\u2010inactivated VZV. The VZV\u2010specific IFN\u2010\u03b3 levels varied among individuals from prevaccination (baseline) to 6 weeks postvaccination. In most subjects, VZV\u2010specific CMI was increased at 6 weeks postvaccination. The HZ vaccine elicited a significant increase in the VZV\u2010specific CMI response as measured by ELISA; the geometric mean fold\u2010rises from baseline to 6 weeks postvaccination were 3.50, 4.22, and 5.24 in the 4.3, 4.7, and 4.9\u2009log plaque\u2010forming unit vaccine groups, respectively, which was significantly higher than in the placebo group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). These results indicate that vaccination enhances the VZV\u2010specific CMI responses in subjects; IFN\u2010\u03b3 ELISA is an effective method for evaluating the CMI response and may be useful for identifying individuals at a high risk of HZ infection.<\/jats:p>","DOI":"10.1002\/jmv.25391","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T02:46:34Z","timestamp":1546829194000},"page":"829-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Varicella\u2010zoster virus\u2010specific cell\u2010mediated immunity by interferon\u2010\u03b3 Enzyme\u2010Linked Immunosorbent Assay in adults \u226550 years of age administered a herpes zoster vaccine"],"prefix":"10.1002","volume":"91","author":[{"given":"Ping","family":"Yang","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University Changchun 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