{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:35:40Z","timestamp":1787067340901,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brazilian National Research Council - CNPQ","award":["(no. 14\/2009)"],"award-info":[{"award-number":["(no. 14\/2009)"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Acute gastroenteritis (AGE) is a significant cause of child mortality worldwide. In Brazil, despite the reduction in infant mortality achieved in recent years, many children still die because of undiagnosed AGE. The prevalence, viral load, and circulating genotypes of rotavirus A (RVA), human adenovirus (HAdV), and norovirus GII (NoV GII) were investigated in children with AGE during 12 months in Vitoria, Esp\u00edrito Santo, Southeastern Brazil. Enteric viruses were detected in stool samples, quantified by quantitative polymerase chain reaction, sequenced, and compared phylogenetically. The overall prevalence was 93.3% (125\/134). Cases of single infection (41.8%) and mixed infection (51.5%) were observed; in 21.6% of cases, all the three viruses were detected. RVA had the highest number of copies in all infections. Phylogenetic analysis revealed predominantly the presence of RVA genotype G3, followed by G2 and G9. HAdV clustered within subgroup C, but some samples harbored subgroups A, D, or F. All sequenced NoV\u2010positive samples clustered within the prevalent genotype GII.4. The high prevalence of RVA, HAdV, and NoV in diarrheal feces clarifies the etiology of AGE in this population, and the presence of RVA in vaccinated children reinforces the importance of monitoring programs to identify the causes of gastroenteritis and contribute to the reliability of diagnosis.<\/jats:p>","DOI":"10.1002\/jmv.25392","type":"journal-article","created":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T21:45:39Z","timestamp":1546811139000},"page":"744-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["High prevalence of enteric viruses associated with acute gastroenteritis in pediatric patients in a low\u2010income area in Vit\u00f3ria, Southeastern Brazil"],"prefix":"10.1002","volume":"91","author":[{"given":"Rodrigo","family":"Pratte\u2010Santos","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Saneamento, Universidade Federal do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marize Pereira","family":"Miagostovich","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Comparada e Ambiental, Instituto Oswaldo Cruz\u2014Fiocruz Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00falio Machado","family":"Fumian","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Comparada e Ambiental, Instituto Oswaldo Cruz\u2014Fiocruz Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel Leonor","family":"Maciel","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Epidemiologia, Universidade Federal do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Angelino","family":"Martins","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Saneamento, Universidade Federal do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rvio T\u00falio","family":"Cassini","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Saneamento, Universidade Federal do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-0715","authenticated-orcid":false,"given":"Regina","family":"Keller","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Saneamento, Universidade Federal do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"e_1_2_8_1_2_1","unstructured":"UNICEFAnnual Report [updated 2015; cited 2017 Dec 27]. Available from:https:\/\/data.unicef.org\/wp\u2010content\/uploads\/2016\/11\/UNICEF\u2010Pneumonia\u2010Diarrhoea\u2010report2016\u2010web\u2010version_final.pdf\/"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jped.2012.10.002","article-title":"Temporal trends of overall mortality and hospital morbidity due to diarrheal disease in Brazilian children younger than 5 years from 2000 to 2010","volume":"89","author":"Mendes PSA","year":"2013","journal-title":"J Pediatr"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-7069(07)17001-4"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.10.009"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60222-6"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2012.00469.x"},{"key":"e_1_2_8_1_8_1","unstructured":"Organizaci\u00f3n Panamericana De La Salud. Mapa de introduccion de las nuevas vacunas. 2014 [cited 2014 May 26]; Available from:http:\/\/www.paho.org\/hq\/index.php?option=com_content&view=article&id=1857&Itemid=1628&lang=es"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.04.037"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.28.3.495-503.1990"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(98)00168-2"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(97)00041-X"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.2.498-505.2001"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.08.004"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.9.4523-4533.2002"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.4.1548-1557.2003"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31828c3de4"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760140381"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05079-0"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052434"},{"key":"e_1_2_8_1_22_1","unstructured":"WHO. [updated 2017; cited 2018 Mar 6].http:\/\/www.who.int\/entity\/immunization\/monitoring_surveillance\/resources\/2017_Rotavirus_PediatricDiarrhea_Surveillance_Meeting_Report.pdf\/"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23797"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24404"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2006.11.005"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.5455\/jicm.9.20160610"},{"key":"e_1_2_8_1_27_1","volume-title":"Fields virology","author":"Fields BN","year":"1990"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160030"},{"key":"e_1_2_8_1_29_1","first-page":"1","article-title":"Epidemiological and molecular analysis of a waterborne outbreak of norovirus GII.4","volume":"8","author":"Zhou X","year":"2012","journal-title":"Epidemiol Infect"},{"key":"e_1_2_8_1_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145391"},{"key":"e_1_2_8_1_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762011000800008"},{"key":"e_1_2_8_1_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056608"},{"key":"e_1_2_8_1_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160357"},{"key":"e_1_2_8_1_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-0276140066"},{"key":"e_1_2_8_1_35_1","doi-asserted-by":"publisher","DOI":"10.2166\/wh.2013.245"},{"key":"e_1_2_8_1_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01232"},{"key":"e_1_2_8_1_37_1","unstructured":"Brasil. [updated 2015; cited 2018 Mar 7]. Available from:http:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2015\/novembro\/09\/Apresenta\u2010\u2010\u2010\u2010o\u2010dados\u2010gerais\u2010DTA\u20102015.pdf"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T08:21:55Z","timestamp":1694679715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,12]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/jmv.25392"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25392","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,12]]},"assertion":[{"value":"2018-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}