{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:23:15Z","timestamp":1768454595582,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Hepatitis B virus (HBV) infection is one of the clinical dilemmas in chronic liver diseases. MicroRNAs (miRNAs) are small noncoding RNA molecules that play an important role in the pathogenesis of liver diseases and single nucleotide polymorphisms (SNPs) in miRNA genes affect the clinical course of HBV infection. Previous studies have shown that miRNA\u2010146a rs2910164 polymorphism can be associated with the pathogenesis of liver diseases such as hepatocellular carcinoma. The present study investigated the association between miRNA\u2010146a rs2910164 polymorphism and susceptibility to HBV infection in an Iranian population.<\/jats:p><jats:p>The study comprised 266 patients with chronic HBV infection, 172 patients with spontaneous viral clearance (SVC) after acute HBV infection, and 266 healthy control adjusted for sex and age. The genotyping of the miRNA\u2010146a rs2910164 polymorphism was performed by polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) method.<\/jats:p><jats:p>Our data revealed that GG genotype and G allele of miRNA\u2010146a rs2910164 SNP is dominated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in patients with chronic HBV infection (Odds ratio [OR]\u2009=\u20093.92; 95% confidence interval [CI]\u2009=\u20092.1\u20107.32). miRNA\u2010146a rs2910164 polymorphism showed a statistically significant association (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) between CC genotype and allele C with SVC (OR\u2009=\u20092.92; 95% CI\u2009=\u20091.56\u2010546).<\/jats:p><jats:p>Our findings suggest miRNA\u2010146a SNP (C\/G) in our population may be associated with the susceptibility to HBV infection and CC genotype is associated with SVC. Also, the GG genotype and G allele at miRNA\u2010146a rs2910164 is associated with chronic HBV infection in our population.<\/jats:p>","DOI":"10.1002\/jmv.25394","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T16:37:12Z","timestamp":1547051832000},"page":"1063-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between miRNA\u2010146a rs2910164 (G\/C) polymorphism with the susceptibility to chronic HBV infection and spontaneous viral clearance in an Iranian population"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-5446","authenticated-orcid":false,"given":"Sayyad","family":"Khanizadeh","sequence":"first","affiliation":[{"name":"Hepatitis Research Center, Lorestan University of Medical Sciences Khorramabad Iran"},{"name":"Department of Virology School of Medicine, Lorestan University of Medical Sciences Khorramabad 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