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Currently, there are still no effective clinical treatments for neuronal injury caused by neurotropic viruses. Memantine, a drug capable of passing through the blood\u2010brain barrier, noncompetitively and reversibly binds to <jats:sc>n<\/jats:sc>\u2010methyl\u2010\n<jats:sc>d<\/jats:sc>\u2010aspartic acid (NMDA) receptors. Memantine is used to treat Alzheimer's disease by blocking the activation of extra axonal ion channels, thus preventing neuronal degeneration by inhibiting the abnormal cytosolic Ca\n<jats:sup>2+<\/jats:sup> increase. To explore whether memantine can alleviate neurological disturbances caused by RABV and JEV, the following experiments were carried out: (1) for primary neurons cultured in vitro infected with RABV, the addition of memantine showed neuroprotection. (2) In the RABV challenge experiments, memantine had limited therapeutic effect, mildly extending the survival time of mice. In contrast, memantine significantly prolonged the survival time of mice infected with JEV, by reducing the intravascular cuff and inflammatory cell infiltration in mice. Furthermore, memantine decreases the amount of JEV virus in mice brain.<\/jats:p>","DOI":"10.1002\/jmv.25396","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T16:34:27Z","timestamp":1547051667000},"page":"935-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Memantine can relieve the neuronal impairment caused by neurotropic virus infection"],"prefix":"10.1002","volume":"91","author":[{"given":"Leqiang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Animal Medicine, College of Veterinary Medicine, Huazhong Agricultural University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research and Development Department, State Key Laboratory of Development of Antibody Drugs, North China Pharmaceutical Group Corporation Shijiazhuang 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