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Virus\u2010like particles (VLPs) as an advantageous antigen can induce significant specific immune response. To improve immunity of VLPs, especially, make it induce persistent immune response, the hollow mesoporous silica nanoparticles (HMSNs) as a potential nano\u2010adjuvant were synthesized and loaded the FMD virus (FMDV) VLPs. They were injected into guinea pigs and the specific immune response was detected. The results confirmed that HMSNs\/VLPs can induce persistent humoral immunity with high\u2010level antibody titer for more than three months. HMSNs also improve the T\u2010lymphocyte proliferation and IFN\u2010\u03b3 induced by FMDV VLPs, and provides the ideal protection against FMDV challenge. These consequences indicated that HMSNs were good protein delivery vehicle and potential nano\u2010adjuvant of vaccines.<\/jats:p>","DOI":"10.1002\/jmv.25417","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T05:43:15Z","timestamp":1548913395000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hollow mesoporous silica nanoparticles as delivery vehicle of foot\u2010and\u2010mouth disease virus\u2010like particles induce persistent immune responses in guinea pigs"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-3699","authenticated-orcid":false,"given":"Manyuan","family":"Bai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology and Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Lanzhou Gansu P. 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