{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:41:12Z","timestamp":1770828072741,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Ref. CM16\/00200"],"award-info":[{"award-number":["Ref. CM16\/00200"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been reported that low\u2010plasma cytomegalovirus (CMV) DNA loads are associated with an increased risk of overall mortality in allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Utilizing a conservative strategy for initiation of preemptive antiviral therapy (&gt;1500 IU\/mL), we characterized the virological features of spontaneously\u2010resolving episodes of CMV DNAemia and assessed their impact on mortality through the first year after transplantation. We reviewed the CMV DNA polymerase chain reaction results and clinical charts of 230 consecutive adult patients who underwent T\u2010cell replete allo\u2010HSCT at our center. A total of 280 episodes of CMV DNAemia were registered in 164 patients, of which 144 episodes cleared spontaneously. Clearance of CMV DNAemia was significantly delayed in initial and recurrent self\u2010resolving episodes featuring CMV DNA peak loads\u2009&gt;\u2009250 IU\/mL compared with those displaying lower values. All\u2010cause mortality in patients with self\u2010resolving episodes of CMV DNAemia was comparable (<jats:italic>P<\/jats:italic>\u2009=\u20090.7) to that in patients with no CMV DNAemia and was not related to the CMV DNA peak load (\u2265250 IU\/mL vs &lt;250 IU\/mL) (<jats:italic>P<\/jats:italic>\u2009=\u20090.6). In summary, in our setting, the magnitude of the CMV DNA peak load reached during self\u2010resolving episodes of CMV DNAemia correlated directly with duration of episodes, but had no apparent impact on all\u2010cause mortality taking patients with no documented CMV DNAemia as a reference.<\/jats:p>","DOI":"10.1002\/jmv.25426","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T15:06:56Z","timestamp":1549638416000},"page":"1128-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spontaneously\u2010resolving episodes of cytomegalovirus DNAemia in allogeneic hematopoietic stem cell transplant recipients: Virological features and clinical outcomes"],"prefix":"10.1002","volume":"91","author":[{"given":"Alberto","family":"Talaya","sequence":"first","affiliation":[{"name":"Microbiology Service, Hospital Cl\u00ednico Universitario, INCLIVA Research Institute Valencia 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