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Here, we further tested 14 additional antimalarial drugs and their metabolites or analogs for anti\u2010ZIKV activity using a phenotypic screening approach. We identified four compounds with varying anti\u2010ZIKV activity, including a metabolite of amodiaquine termed desethylamodiaquine (DAQ) and <jats:italic>N<\/jats:italic>\u2010desethylchloroquine (DECQ), a metabolite of chloroquine, which both exhibited low micromolar effective concentrations against three different ZIKV strains. Two other compounds termed dihydroartemisinin (DHA) and quinidine (QD) exhibited only partial inhibition of ZIKV replication. Characterization of the inhibitory mechanisms of DAQ and DECQ showed that both drugs target the entry step as well as postentry events of the viral replication cycle. These hits represent attractive starting points for future optimization of new anti\u2010ZIKV drug candidates derived from antimalarial drugs and their analogs.<\/jats:p>","DOI":"10.1002\/jmv.25440","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T01:28:38Z","timestamp":1551144518000},"page":"1182-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Antimalarial drugs and their metabolites are potent Zika virus inhibitors"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0307-0843","authenticated-orcid":false,"given":"Yingshan","family":"Han","sequence":"first","affiliation":[{"name":"McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanh 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