{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:43Z","timestamp":1740104143003,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Social Development Guidance Plan of Xi'an Science and Technology Project","award":["SF1424"],"award-info":[{"award-number":["SF1424"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The number of men who have sex with men (MSM) living with human immunodeficiency virus (HIV) in China has increased rapidly and thus immediate highly active antiretroviral therapy (HAART) after diagnosis was implemented as a strategy to reduce the HIV transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MSM who were diagnosed with HIV and received HAART between 2013 to 2015 in Xi\u2019an were divided into three groups (&gt;350, 200\u2010350, and &lt;200 cell\/\u03bcL) according to their baseline CD4+ T cell count. The time of follow\u2010up was calculated from the first date of receiving HAART to December 31, 2016. The CD4+ T cell count was detected with 1 week before or after HAART. The plasma viral loads were tested after 1, 2, and 3 years of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1442 subjects who received HAART, 690 (47.9%) cases were in &gt;350 cell\/\u03bcL group, whereas 400 (27.7%) cases and 352 (24.4%) cases were in the 200\u2010350 cell\/\u03bcL group and &lt;200 cell\/\u03bcL group, respectively. After 1 year of treatment, the viral suppression rate in the &lt;200 cell\/\u03bcL group was 91.1%, which was significantly lower than the other two groups. The logistic regression results show that the &gt;350 cell\/\u03bcL group and 200\u2010350 cell\/\u03bcL group predicted higher viral suppression rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baseline CD4+ T cell count more than 350 cell\/\u03bcL can improve viral suppression among MSM living with HIV. Furthermore, to reduce the transmission risk, the treatment compliance of people living with HIV with high CD4+ T cell levels should be improved, and their diagnosis to the treatment time should be decreased.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.25449","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T18:49:16Z","timestamp":1551898156000},"page":"1263-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of early highly active antiretroviral therapy on viral suppression among newly diagnosed men who have sex with men living with human immunodeficiency virus in Xi'an, China"],"prefix":"10.1002","volume":"91","author":[{"given":"Xiaoli","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Sexually Transmitted Diseases Prevention and Control Xi\u2019an Centers for Disease Control and Prevention Xi\u2019an 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