{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:02:34Z","timestamp":1770235354818,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.71\u2010373\u2010166"],"award-info":[{"award-number":["No.71\u2010373\u2010166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71\u2010373\u2010166"],"award-info":[{"award-number":["71\u2010373\u2010166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low\u2010cost, accurate high\u2010risk human papillomavirus (HR\u2010HPV) tests are needed for cervical cancer screening in limited\u2010resource settings. More than 200 cervical cytological specimens from hospital patients were collected and analyzed for a real\u2010world study. We evaluated the analytical and clinical performance of four widely used HR\u2010HPV test (Tellgen, Hybribio, Liferiver, and Sansure) based on real\u2010time polymerase chain reaction technology platforms, compared with the cobas test. Cervical intraepithelial neoplasia grade 2 or worse lesions (CIN2+) were set as the disease endpoint, and all the five HPV tests were performed with equal sensitivity (McNemar's test; <jats:italic>P<\/jats:italic>\u2009=\u20090.971) and specificity (McNemar's test; <jats:italic>P<\/jats:italic>\u2009=\u20090.953). All genotyping using the INNO\u2010LiPA HPV test showed that HPV\u201016, \u201052, and \u201054 were the most common types among CIN2+ cases. Overall, the four HR\u2010HPV tests analyzed appear to be as effective as the cobas HPV test in both agreement and clinical performance. Therefore, each of these low\u2010cost HPV test kits could be implemented in limited\u2010resource settings to accelerate the control of cervical cancer. However, we suggest that there is a need to further standardize and optimize testing around clinical sensitivity and specificity.<\/jats:p>","DOI":"10.1002\/jmv.25451","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T01:30:32Z","timestamp":1552267832000},"page":"1342-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A direct comparison of four high\u2010risk human papillomavirus tests versus the cobas test: Detecting CIN2+ in low\u2010resource settings"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-8146","authenticated-orcid":false,"given":"Peng","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Women's Health Care Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing Maternal and Child Health Care Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Li","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Women's Health Care Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing Maternal and Child Health Care Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Seery","sequence":"additional","affiliation":[{"name":"School of 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-0056","authenticated-orcid":false,"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Women's Health Care Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing Maternal and Child Health Care Hospital Beijing 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