{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:53Z","timestamp":1740104153493,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Wisteria floribunda<\/jats:italic> agglutinin\u2010positive Mac\u20102\u2010binding protein (M2BP) has been identified as a predictor for the response of interferon \u03b1 (IFN\u2010\u03b1) in patients with viral hepatitis. However, whether serum glycosylation isomer of M2BP (M2BPGi) was associated with the regression of liver fibrosis in patients with chronic hepatitis B (CHB) during IFN\u2010\u03b1 add\u2010on therapy is still unknown. CHB patients were treated with entecavir for 26 weeks followed by entecavir plus pegylated IFN\u2010\u03b1 for 52 weeks. Liver biopsies were taken at baseline and treatment week 78. The regression of fibrosis was identified according to Ishak standard or Ishak plus Progressive\u2010Indeterminate\u2010Regressive (P\u2010I\u2010R) standard. Serum M2BPGi and liver function tests were measured at baseline and every 26 weeks of treatment. A total of 72 CHB patients were included in the present study. Serum M2BPGi was correlated with fibrosis and necroinflammation both at baseline and week 78. If Ishak standard was used as the reference, only the percent change of M2BPGi at week 52 from week 26 (\u0394%M2BPGi<jats:sub>26w\u201052W<\/jats:sub>) was independently associated with fibrosis regression at treatment week 78, the area under the ROC curve (AUROC) of \u0394%M2BPGi<jats:sub>26w\u201052W<\/jats:sub> for predicting fibrosis regression was 0.705. As for Ishak plus P\u2010I\u2010R standard, the AUROC of the predictive model for fibrosis regression (0.896*M2BPGi<jats:sub>52W<\/jats:sub>\u2009+\u20090.363*necroinflammation score<jats:sub>0w<\/jats:sub>\u2009+\u20092.051*Ishak score<jats:sub>0w<\/jats:sub>\u2009\u2013\u20094.489) was 0.888. These data indicated that dynamic changes of serum M2BPGi were associated with fibrosis regression in CHB patients on IFN\u2010\u03b1 add\u2010on therapy.<\/jats:p>","DOI":"10.1002\/jmv.25465","type":"journal-article","created":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T11:50:10Z","timestamp":1553428210000},"page":"1499-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["On\u2010treatment changes of serum <i>Wisteria floribunda<\/i> agglutinin\u2010positive Mac\u20102 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon \u03b1 add\u2010on therapy"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-3016","authenticated-orcid":false,"given":"Tianhui","family":"Liu","sequence":"first","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yameng","family":"Sun","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Biomedicine Ministry of Education, Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Biomedicine Ministry of Education, Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Wu","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongpeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Piao","sequence":"additional","affiliation":[{"name":"Department of\u00a0Infectious\u00a0Diseases Affiliated Hospital of Yanbian University Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lungen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Digestive System Beijing Tiantan Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"Hepatology Institute Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuemin","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Traditional and Western Medical Hepatology Third Hospital of Hebei Medical University, Shijiazhuang Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[{"name":"Center of Liver Diseases Beijing Ditan Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Second Liver Cirrhosis Diagnosis and Treatment Center Military Hospital of China Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Fifth Hospital of Shijiazhuang City Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine Affiliated Hospital, Logistics University of People's Armed Police Force Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiguo","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Beijing Youan Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Youan Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tailing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Evidence\u2010Based Medicine Unit National Clinical Research Center for Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Kong","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Evidence\u2010Based Medicine Unit National Clinical Research Center for Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Cong","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Biomedicine Ministry of Education, Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"You","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidong","family":"Jia","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis &amp; National Clinical Research Center of Digestive Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21627"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21513"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23785"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61425-1"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.020"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12710"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21179-2"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29009"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.022"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2001.155"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1016\/S0021-9258(19)85233-X","article-title":"Cloning and characterization of a human MAC\u20102\u2010binding protein, a new member of the superfamily defined by the macrophages scavenger receptor cysteine\u2010rich domain","volume":"268","author":"Koths K","year":"1993","journal-title":"J Biol Chem"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1016\/S0021-9258(17)33112-5","article-title":"Purification and characterization of a lectin from Wisteria floribunda seeds","volume":"251","author":"Kurokawa T","year":"1976","journal-title":"J Biol Chem"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13188"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-0946-y"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1007-2"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.118"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-016-9754-1"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25010"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80076-6"},{"key":"e_1_2_7_1_22_1","first-page":"11","volume-title":"Scheuer's Liver Biopsy Interpretation","author":"Lefkowitch JH","year":"2015"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12703"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-016-9754-1"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5421.1835"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12078"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32322-0"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:45:56Z","timestamp":1694331956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/jmv.25465"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25465","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"assertion":[{"value":"2018-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}