{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:50:20Z","timestamp":1791989420805,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["Q201617"],"award-info":[{"award-number":["Q201617"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain dysfunction is a prerequisite for critical complications in children with hand, foot, and mouth disease (HFMD). Aquaporin 4 (AQP\u20104) may be involved in the pathological process of cerebral oedema and injury in children with severe and critical HFMD. This study aimed to assess the association of AQP\u20104 with the severity of enterovirus 71 (EV71)\u2013associated HFMD. Children with EV71\u2010infected HFMD were divided into a common group (clinical stage 1), a severe group (clinical stage 2), and a critical group (clinical stage 3) according to Chinese guidelines. The levels of AQP\u20104, interleukin\u20106 (IL\u20106), norepinephrine (NE), and neuron\u2010specific enolase (NSE) before and after treatment were tested. Serum AQP\u20104, IL\u20106, NE, and NSE levels showed significant differences among the critical, severe, and common groups before and after treatment (<jats:italic>P<\/jats:italic>\u2002&lt;\u20020.01). No significant differences in AQP\u20104 levels in cerebrospinal fluid (CSF) were observed between the critical and severe groups before and after treatment, but the CSF AQP\u20104 levels in these two groups were higher than those in the common group before treatment (<jats:italic>P<\/jats:italic>\u2002&lt;\u20020.01). Serum AQP\u20104 levels, but not CSF AQP\u20104 levels, closely correlated with serum IL\u20106, NE, and NSE levels. These results suggest that the level of AQP\u20104 in serum, but not in CSF, is a candidate biomarker for evaluating the severity and prognosis of EV71\u2010associated HFMD.<\/jats:p>","DOI":"10.1002\/jmv.25475","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T14:35:02Z","timestamp":1554302102000},"page":"587-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Distinct expression and clinical value of aquaporin 4 in children with hand, foot and mouth disease caused by enterovirus 71"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-2093","authenticated-orcid":false,"given":"Lei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit Xuzhou Children's Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xuzhou Children's Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong\u2010jian","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Xuzhou Children's Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010song","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Xuzhou Children's Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Xuzhou Children's Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010xiang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Xuzhou Children's Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.11.021"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25282"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182771364"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010015\u20100965\u20101"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.09.012"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000637"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2018.4156"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.7499\/j.issn.1008\u20108830.2017.02.011"},{"issue":"13","key":"e_1_2_9_1_10_1","first-page":"4224","article-title":"Using changes in pro\u2010brain natriuretic peptide of plasma amino\u2010terminal and norepinephrine levels as prognostic and diagnostic factors in hand\u2010foot\u2010and\u2010mouth disease","volume":"22","author":"Zhu L","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2018.1416257"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33330"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.03.055"},{"key":"e_1_2_9_1_14_1","unstructured":"Ministry of Health of the People's Republic of China. Guidelines for the diagnosis and treatment of hand foot and mouth disease (2010 edition).\u00a0http:\/\/www.nhc.gov.cn\/yzygj\/s3593g\/201306\/6d935c0f43cd4a1fb46f8f71acf8e245.shtml(in Chinese) Accessed February 8 2017."},{"key":"e_1_2_9_1_15_1","unstructured":"Clinical Experts Group of the Ministry of Health for Hand Foot and Mouth Disease.Experts consensus on rescue and treatment of severe cases with enterovirus 71 (EV71) infection.Chin J Pediatr. 49;2011(9):675\u2010678.https:\/\/doi.org\/10.3760\/cma.j.issn.0578\u20101310.2011.09.007"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.082"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010015\u20100504\u2010y"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010018\u20102549\u20100"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010012\u20101233\u20104"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.03.036"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ahe.12210"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010013\u20109905\u2010z"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.10.021"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6324"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2016.1144410"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006585"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00082"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25475","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:10:25Z","timestamp":1692947425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,23]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jmv.25475"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25475","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,23]]},"assertion":[{"value":"2019-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}