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One strategy proposed to eradicate these reservoirs is the \u201cshock and kill\u201d approach, where latency\u2010reversing agents (LRAs) are used to reactivate and promote viral cell death and\/or immune killing of reactivated cells. Here, we report that curaxin CBL0137, an antitumor compound, can potentiate tumor necrosis factor\u2010\u03b1\u2010mediated reactivation of latently infected HIV\u20101cell lines. Additionally, the single use of CBL0137 is sufficient to reactivate HIV\u20101 latent reservoirs in peripheral mononuclear cells (PBMCs) isolated from HIV\u20101 positive, cART\u2010treated, aviremic patients. Thus, CBL0137 possesses capabilities as a LRA and could be considered for the \u201cshock and kill\u201d approach.<\/jats:p>","DOI":"10.1002\/jmv.25487","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T07:04:06Z","timestamp":1555398246000},"page":"1571-1576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Curaxin CBL0137 has the potential to reverse HIV\u20101 latency"],"prefix":"10.1002","volume":"91","author":[{"given":"Maxime J.","family":"Jean","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Rochester Medical Center Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Fiches","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huachao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Purmal","sequence":"additional","affiliation":[{"name":"Division of Chemistry Incuron LLC Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Gurova","sequence":"additional","affiliation":[{"name":"Department of Cell Stress Biology Roswell Park Cancer Institute Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Netty G.","family":"Santoso","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-8320","authenticated-orcid":false,"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"key":"e_1_2_8_1_2_1","unstructured":"UNAIDS. 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