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In this study, we describe clinical manifestations of 94 suspected cases of congenital Zika from Bahia state, Brazil, and the results of serological tests performed on children and\/or their mothers at an average of 71 days after birth. Anti\u2010Zika immunoglobulin M (IgM) antibodies were detected in 44.4% and in 7.1% of samples from mothers and children, respectively. Nearly all the IgM, and 92% of immunoglobulin G positive results were confirmed by neutralization test. Zika specific neutralizing antibodies were detected in as much as 90.4% of the cases. Moreover, dengue specific neutralizing antibodies were detected in 79.0% of Zika seropositive mothers. In conclusion, Zika IgM negative results should be considered with caution, due to a possible rapid loss of sensitivity after birth, while the NS1\u2010based Zika IgM enzyme\u2010linked immunosorbent assay test we have used has demonstrated to be highly specific. In a high percentage of cases, Zika specific neutralizing antibodies were detected, which are indicative of a past Zika infection, probably occurred during pregnancy in this population.<\/jats:p>","DOI":"10.1002\/jmv.25504","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T09:10:04Z","timestamp":1557911404000},"page":"1577-1583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiological and clinical suspicion of congenital Zika virus infection: Serological findings in mothers and children from Brazil"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9078-8350","authenticated-orcid":false,"given":"Giulietta","family":"Venturi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fortuna","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita Maria","family":"Alves","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Service S. 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