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Previously reported data highlights the risk of drug\u2010induced hepatotoxicity associated with three of the first\u2010line anti\u2010TB agents: rifampin, isoniazid, and pyrazinamide specifically in patients coinfected with HIV and HCV. Thus far, direct\u2010acting antiviral (DAA) drug\u2010induced hepatotoxicity has not been reported in the literature but herein, we observed an unusual case of HCV virological breakthrough and hepatoxicity during treatment with DAA drugs in a patient who has previously been successfully treated for TB.<\/jats:p>","DOI":"10.1002\/jmv.25557","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T09:30:09Z","timestamp":1564133409000},"page":"2195-2197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hepatotoxicity and virological breakthrough of HCV following treatment with sofosbuvir, daclatasvir, and ribavirin in patients previously treated for tuberculosis"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-6365","authenticated-orcid":false,"given":"Braira","family":"Wahid","sequence":"first","affiliation":[{"name":"Department of Life Sciences, School of Science University of Management and Technology  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"e_1_2_6_1_2_1","unstructured":"World Health Organization.Global Tuberculosis Report 2013. 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