{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:45:15Z","timestamp":1779345915950,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to evaluate the significance of the RANTES\u2010CCR5 axis and resulting immunomodulatory status in Dengue pathogenesis involving a Guwahati, India based population where Dengue cases have increased alarmingly. An increased CC\u2010chemokine receptor type 5 (CCR5) messenger RNA expression and CCR5 positive cell count profile was observed in Dengue cases, the highest being in severe cases. CCR5 ligand RANTES expression was significantly decreased in Dengue cases and inversely correlated with Dengue viremia fold change in severe cases. Monocytes are involved in Dengue virus homing and replication. Its levels and activation profile were higher in Dengue cases. A hyper Th1\u2010biased immunomodulatory profile with upregulated tumor necrosis factor\u2010\u03b1 levels, and downregulated expression of antiviral cytokine interferon\u2010\u03b3 and key regulatory Th2 anti\u2010inflammatory cytokine interleukin 10 was observed in severe Dengue cases compared with mild Dengue cases and controls. The results, therefore, suggest the significance of RANTES\u2010CCR5 axis deregulation and resulting altered immunomodulation in Dengue pathogenesis, and holds prognostic and therapeutic significance.<\/jats:p>","DOI":"10.1002\/jmv.25561","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T09:18:54Z","timestamp":1564651134000},"page":"2066-2073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Significance of RANTES\u2010CCR5 axis and linked downstream immunomodulation in Dengue pathogenesis: A study from Guwahati, India"],"prefix":"10.1002","volume":"91","author":[{"given":"Mafidul","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Biotechnology Gauhati University  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trishna","family":"Kalita","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Gauhati University  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan K.","family":"Saikia","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology GNRC Hospital  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjuma","family":"Begum","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Gauhati University  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-7785","authenticated-orcid":false,"given":"Vargab","family":"Baruah","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Gauhati University  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Gauhati University  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raktim","family":"Borkotoky","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Gauhati University  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-958X","authenticated-orcid":false,"given":"Sujoy","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Gauhati University  Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"e_1_2_9_1_2_1","volume-title":"Dengue: Guidelines for Diagnosis. 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