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The frequency of HIV\u20101 IN mutations in 2177 treatment\u2010na\u00efve subjects was investigated, along with the INSTI susceptibility of site\u2010directed mutant viruses containing major and minor INSTI\u2010R mutations. Total 6 of 39 minor INSTI\u2010R mutations (M50I, S119P\/G\/T\/R, and E157Q) were found in &gt;1% of IN\u2010treatment\u2010na\u00efve subjects with no impact on INSTI susceptibility. When each combined with major INSTI\u2010R mutation, M50I, S119P, and E157Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.<\/jats:p>","DOI":"10.1002\/jmv.25564","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T08:01:07Z","timestamp":1565164867000},"page":"2188-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Antiviral activity of HIV\u20101 integrase strand\u2010transfer inhibitors against mutants with integrase resistance\u2010associated mutations and their frequency in treatment\u2010na\u00efve individuals"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-4237","authenticated-orcid":false,"given":"Nicolas A.","family":"Margot","sequence":"first","affiliation":[{"name":"Gilead Sciences, Inc. 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