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However, the expression of Arrb2 in microglial cells and its influence on HSE prognosis is still undefined. We explore the pathophysiological effect of Arrb2 in the brain using experimental HSE mice. The expression of Arrb2 in microglia was decreased significantly 48\u2009hours following HSV\u20101 infection. Arrb2 overexpression transgenic (TG) mice had a significantly lower mortality and survival rate was improved by 40% compared to wild\u2010type mice. Arrb2 suppressed the generation of proinflammatory cytokines TNF\u2010\u03b1 and IL\u20106 and increased anti\u2010inflammatory cytokines IL\u201010 and IL\u20104 expression. Arrb2 also inhibited the activation of the transcription factor NF\u2010\u03baB in microglial cells. Arrb2 TG mice attenuated the blood\u2010brain barrier breakdown and relieved cerebral edema, meanwhile, Arrb2 improved mice neurological function compared with wild\u2010type mice. Overall, Arrb2 favored microglia of the M2 phenotype, attenuated brain proinflammatory responses, protected the blood vessel wall integrity, reduced HSV\u20101\u2010induced neurological impairment, and improved the survival rate in HSE mice.<\/jats:p>","DOI":"10.1002\/jmv.25578","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T09:11:57Z","timestamp":1567156317000},"page":"78-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["\u03b2\u2010Arrestin 2 protects against neurological function defects in HSV\u20101\u2010induced encephalitis mice"],"prefix":"10.1002","volume":"92","author":[{"given":"Yanping","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Neurology, Renmin Hospital Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department 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