{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:05:43Z","timestamp":1761663943994,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CRRPG3F0053"],"award-info":[{"award-number":["CRRPG3F0053"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["107\u20102314\u2010B\u2010182\u2010004\u2010MY3"],"award-info":[{"award-number":["107\u20102314\u2010B\u2010182\u2010004\u2010MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the seroprevalence change of anti\u2010hepatitis D virus (HDV) antibodies in Taiwan from 2006 to 2019. A total of 1147 patients who had chronic hepatitis B virus (HBV) infection were assessed. Of them, 51 (4.4%) were positive for anti\u2010HDV antibodies. Comparison between anti\u2010HDV\u2010positive and negative groups was performed to examine clinical and virological factors related to anti\u2010HDV positivity. It was found that the median HBV\u2010DNA concentration was 1.6\u2009\u00d7\u200910<jats:sup>5<\/jats:sup>\u2009IU\/mL (range, &lt;20\u20104.5\u2009\u00d7\u200910<jats:sup>10<\/jats:sup>\u2009IU\/mL) and &lt;20\u2009IU\/mL (range, &lt;20\u20102.0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\u2009IU\/mL) for patients with negative and positive anti\u2010HDV antibodies, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). In addition, a progressive year\u2010to\u2010year decrease of anti\u2010HDV seroprevalence was unveiled. For patients who had HBV\u2010DNA &gt;15\u2009000\u2009IU\/mL, the year\u2010to\u2010year (calculated every 2 years) seropositive rates of anti\u2010HDV were 10.0%, 7.9%, 0.7%, 0.3%, 0%, 0%, and 0% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). For patients who had HBV\u2010DNA &lt;15\u2009000\u2009IU\/mL, the year\u2010to\u2010year seropositive rates were 18.6%, 12.8%, 7.8%, 5.0%, 7.3%, 8.0%, and 3.7% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). In conclusion, seropositive of anti\u2010HDV was inversely associated with HBV\u2010DNA levels. A progressive decrease of anti\u2010HDV seroprevalence was found with no anti\u2010HDV\u2010positive cases detected in high HBV\u2010DNA patient group after 2014.<\/jats:p>","DOI":"10.1002\/jmv.25582","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T09:11:55Z","timestamp":1567156315000},"page":"124-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decreasing seroprevalence of anti\u2010hepatitis D virus antibodies in the antiviral era with inverse association with hepatitis B virus DNA, Taiwan, 2006 to 2019"],"prefix":"10.1002","volume":"92","author":[{"given":"Kuan\u2010Chieh","family":"Lee","sequence":"first","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Lang","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Ling","family":"Chang","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wey\u2010Ran","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Wei","family":"Lai","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chao","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010Nan","family":"Chien","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-275X","authenticated-orcid":false,"given":"Chau\u2010Ting","family":"Yeh","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.126"},{"key":"e_1_2_9_1_3_1","first-page":"1","article-title":"Epidemiology of hepatitis delta virus: overview","volume":"364","author":"Rizzetto M","year":"1991","journal-title":"Prog Clin Biol 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