{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:02:25Z","timestamp":1781830945519,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To know the epidemiological context of hand\u2010foot\u2010and\u2010mouth disease (HFMD) in a region of Uruguay and to identify the Enterovirus responsible for an outbreak in a rural childcare center in 2018. Swab samples from skin lesions and\/or stools samples were collected from children suffering HFMD during an outbreak in a rural childcare center. Samples were subject to viral RNA extraction and reverse\u2010transcription polymerase chain reaction towards VP1 coding segment, to identify the Enterovirus type by sequencing and phylogenetic analysis. Total of 149 cases of HFMD affecting 98 boys and 51 girls were reported in Salto Province\u2010Uruguay in 2018. Total 60% of the cases were originated from outbreaks, which occurred in ten educative and childcare institutions from both urban and rural areas. Coxsackievirus\u20106 (CV\u2010A6) was identified as responsible for one of the rural outbreaks. Uruguayan strains were more related to strains reported in Russia, Turkey, and Germany (2014\u20102017) than to strains reported in Brazil and Argentina from 2015 to 2016. This is the first report of CV\u2010A6\u2010associated HFMD in Uruguay, evidencing a wide geographic range of the virus in the Latin American region. Our report also warns about CV\u2010A6\u2010associated HFMD during winter, contrarily to most reports that register HFMD during summer and fall seasons.<\/jats:p>","DOI":"10.1002\/jmv.25590","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T11:54:39Z","timestamp":1568116479000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hand\u2010foot\u2010and\u2010mouth disease in uruguay: Coxsackievirus A6 identified as causative of an outbreak in a rural childcare center"],"prefix":"10.1002","volume":"92","author":[{"given":"Andr\u00e9s","family":"Lizasoain","sequence":"first","affiliation":[{"name":"Laboratorio de Virolog\u00eda Molecular, Departamento de Ciencias Biol\u00f3gicas Universidad de la Rep\u00fablica Salto Salto Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Piegas","sequence":"additional","affiliation":[{"name":"Laboratorio de Virolog\u00eda Molecular, Departamento de Ciencias Biol\u00f3gicas Universidad de la Rep\u00fablica Salto Salto Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Victoria","sequence":"additional","affiliation":[{"name":"Laboratorio de Virolog\u00eda Molecular, Departamento de Ciencias Biol\u00f3gicas Universidad de la Rep\u00fablica Salto Salto Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson E.","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Enterov\u00edrus Funda\u00e7\u00e3o Oswaldo Cruz Rio de Janeiro Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-5383","authenticated-orcid":false,"given":"Rodney","family":"Colina","sequence":"additional","affiliation":[{"name":"Laboratorio de Virolog\u00eda Molecular, Departamento de Ciencias Biol\u00f3gicas Universidad de la Rep\u00fablica Salto Salto Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_2_9_1_2_1","first-page":"855","volume-title":"Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses","author":"Knowles NJ","year":"2012"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.04.023"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4438"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2002.tb00601.x"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24200"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23444"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.04.202"},{"issue":"2","key":"e_1_2_9_1_9_1","first-page":"177","article-title":"Best practices to prevent transmission and control outbreaks of hand, foot, and mouth disease in childcare facilities: a systematic review","volume":"23","author":"Chan JH","year":"2017","journal-title":"Hong Kong Med J"},{"key":"e_1_2_9_1_10_1","unstructured":"Centers for Disease Control and Prevention.Hand foot and mouth disease (HFMD). Causes and transmission. Available from:https:\/\/www.cdc.gov\/hand\u2010foot\u2010mouth\/about\/transmission.html. Accessed June 10 2019."},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1253-1"},{"issue":"8","key":"e_1_2_9_1_12_1","first-page":"615","article-title":"Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; isolation of group A coxsackie virus","volume":"79","author":"Robinson CR","year":"1958","journal-title":"Can Med Assoc J"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.011"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318231d67a"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-21-18"},{"key":"e_1_2_9_1_16_1","first-page":"490","volume-title":"Fields Virology","author":"Pallansch MA","year":"2013"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090438"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.1058156"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12361"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.11.003"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu624"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40402-2"},{"key":"e_1_2_9_1_23_1","unstructured":"National Institute of Statistical.Censos 2011. Contame que te cuento. (Spanish) Available from:http:\/\/www5.ine.gub.uy\/censos2011\/resultadosfinales\/salto.html. Accessed June 10 2019."},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00542-06"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-001-0399-7"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.03.006"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_2_9_1_28_1","first-page":"111","article-title":"Maculopapular vesicular disease of hand, foot, and mouth","volume":"44","author":"Perillo de Aguirrezabala M","year":"1973","journal-title":"First National Observation. Arch Pediatr Urug"},{"key":"e_1_2_9_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-014-2071-x"},{"key":"e_1_2_9_1_30_1","doi-asserted-by":"publisher","DOI":"10.4081\/idr.2014.5627"},{"key":"e_1_2_9_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ram.2018.05.003"},{"key":"e_1_2_9_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.08.012"},{"key":"e_1_2_9_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2018.07.011"},{"key":"e_1_2_9_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12468"},{"key":"e_1_2_9_1_35_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2404.171298"},{"key":"e_1_2_9_1_36_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2853"},{"key":"e_1_2_9_1_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-346"},{"key":"e_1_2_9_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70264-0"},{"key":"e_1_2_9_1_39_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1810.120813"},{"key":"e_1_2_9_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.12.012"},{"key":"e_1_2_9_1_41_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.12.20745"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:59:26Z","timestamp":1694077166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jmv.25590"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25590","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"2019-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}