{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:37:48Z","timestamp":1761745068994,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701632"],"award-info":[{"award-number":["81701632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coxsackievirus A16 (CA16) remains the most common causative agent of hand, foot, and mouth disease (HFMD), and is related to high incidence and critical complications. Vitamin D receptor (VDR) activity might affect the outcome of CA16 infection. Our case\u2010control research aims to evaluate the relationship between VDR polymorphisms in the gene encoding and susceptibility to and severity of HFMD due to CA16. Three single\u2010nucleotide polymorphisms (SNPs) of <jats:italic>VDR<\/jats:italic> gene were selected according to functional prediction and linkage disequilibrium, and were examined utilizing the SNPscan method to identify possible associations with HFMD caused by CA16. A significant relationship was found in the HFMD cases of polymorphism rs11574129 (GA vs GG: odds ratio (OR)\u2009=\u20090.068, 95% confidence interval (CI)\u2009=\u20090.007\u20100.693, <jats:italic>P<\/jats:italic>\u2009=\u2009.023; GA\u2009+\u2009AA vs GG: OR\u2009=\u20090.322, 95%CI\u2009=\u20090.106\u20100.984, <jats:italic>P<\/jats:italic>\u2009=\u2009.047), and vitamin D levels in genotype AA were significantly higher than those in genotype GG (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). These results suggest that VDR rs11574129 may influence genetic susceptibility to CA16\u2010associated HFMD.<\/jats:p>","DOI":"10.1002\/jmv.25603","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T08:49:13Z","timestamp":1570351753000},"page":"271-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of polymorphisms in the vitamin D receptor gene with susceptibility to and severity of hand, foot, and mouth disease caused by coxsackievirus A16"],"prefix":"10.1002","volume":"92","author":[{"given":"Ya\u2010Ping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Xi'an Jiaotong University Second Affiliated Hospital Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Xi'an Jiaotong University Second 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