{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:00:40Z","timestamp":1789592440716,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nasopharyngeal cancer (NPC) is highly prevalent in southern Chinese populations but it is rare in most parts of the world. A few studies were performed in nonendemic regions of the world, and suggested the prognostic value of Epstein\u2010Barr virus (EBV) DNA load in blood. In this study, EBV DNA presence and viral load (VL) level in the blood of patients with NPC in Polish population were presented. In addition, its prognostic value for locoregional control among other clinicopathological features was evaluated. Patients with carcinoma of the nasopharynx treated definitively with radiotherapy or radiochemotherapy were included in the study. Real\u2010time polymerase chain reaction was performed for quantitating of EBV DNA in plasma. Among patients with NPC, 51% (22 of 43) were classified as EBV\u2010positive with the mean of the VL of 4934\u2009\u00b1\u20098693 copies\/mL. Multiple regression analysis between log EBV DNA VL and clinical parameters revealed that the most important factors increasing the VLs were advanced N disease together with no\u2010smoking status and advanced T tumors. Multivariate Cox regression analysis revealed that T3\u2010T4 tumors were an independent prognostic factor for poor locoregional control. Analysis for the subgroup of patients with T1\u2010T2 tumors showed that T1\u2010T2 EBV\u2010negative patients had better locoregional control compared with T1\u2010T2 EBV\u2010positive, though without statistical significance. In conclusion, it seems that EBV DNA determination may have an important role in diagnostics of patients with NPC with T1\u2010T2 tumors indicating a subgroup with poorer prognosis, though it needs to be proven on a larger cohort.<\/jats:p>","DOI":"10.1002\/jmv.25606","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T03:28:36Z","timestamp":1571023716000},"page":"348-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic significance of Epstein\u2010Barr virus viral load in patients with T1\u2010T2 nasopharyngeal cancer"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-4095","authenticated-orcid":false,"given":"Agnieszka M.","family":"Mazurek","sequence":"first","affiliation":[{"name":"Center for Translational Research and Molecular Biology of Cancer Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Wygoda","sequence":"additional","affiliation":[{"name":"I Radiotherapy and Chemotherapy Clinic Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"I Radiotherapy and Chemotherapy Clinic Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Olbryt","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Molecular Biology of Cancer Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Pietrowska","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Molecular Biology of Cancer Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Celejewska","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Sk\u0142adowski","sequence":"additional","affiliation":[{"name":"I Radiotherapy and Chemotherapy Clinic Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Wid\u0142ak","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Molecular Biology of Cancer Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Branch Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"167","article-title":"Descriptive and analytical epidemiology of nasopharyngeal cancer","volume":"20","author":"Hirayama T","year":"1978","journal-title":"IARC Sci Publ"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0353"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.09.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520409"},{"key":"e_1_2_9_6_1","first-page":"706","article-title":"Evidence for a relation of Epstein\u2010Barr virus to Burkitt's lymphoma and nasopharyngeal carcinoma","volume":"36","author":"Henle W","year":"1970","journal-title":"Bibl Haematol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02568.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.66.1.122-131.1992"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113702"},{"key":"e_1_2_9_11_1","first-page":"e113702","article-title":"Can global variation of nasopharynx cancer be retrieved from the combined analyses of IARC Cancer Information (CIN) databases?","volume":"6","author":"Sun X","year":"2011","journal-title":"PLoS One"},{"key":"e_1_2_9_12_1","unstructured":"Didkowska J Wojciechowska U Olasek P. 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