{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:46:02Z","timestamp":1780580762159,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY006360"],"award-info":[{"award-number":["P30EY006360"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["RO1EY024630"],"award-info":[{"award-number":["RO1EY024630"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["T32EY007092"],"award-info":[{"award-number":["T32EY007092"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanisms that contribute to retinal tissue destruction during the onset and progression of AIDS\u2010related human cytomegalovirus (HCMV) retinitis remain unclear. Evidence for the stimulation of multiple cell death pathways including apoptosis, necroptosis, and pyroptosis during the pathogenesis of experimental murine cytomegalovirus (MCMV) retinitis in mice with retrovirus\u2010induced immunosuppression (MAIDS) has been reported. Parthanatos is a caspase\u2010independent cell death pathway mediated by rapid overactivation of poly (ADP\u2010ribose) polymerase\u20101 (PARP\u20101) and distinct from other cell death pathways. Using the MAIDS model of MCMV retinitis, studies were performed to test the hypothesis that intraocular MCMV infection of mice with MAIDS stimulates parthanatos\u2010associated messenger RNAs (mRNAs) and proteins within the eye during the development of retinal necrosis that takes place by 10 days after MCMV infection. MCMV\u2010infected eyes of MAIDS mice exhibited significant stimulation of PARP\u20101 mRNA and proteins at 3 days after infection but declined thereafter at 6 and 10 days after infection. Additional studies showed the intraocular stimulation of mRNAs or proteins before MCMV retinitis development for two additional participants in parthanatos, polymer of ADP\u2010ribose and poly (ADP\u2010ribose) glycohydrolase. These results provide new evidence for a role for parthanatos during MAIDS\u2010related MCMV retinitis that may also extend to AIDS\u2010related HCMV retinitis.<\/jats:p>","DOI":"10.1002\/jmv.25619","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T11:36:34Z","timestamp":1572521794000},"page":"394-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Parthanatos\u2010associated proteins are stimulated intraocularly during development of experimental murine cytomegalovirus retinitis in mice with retrovirus\u2010induced immunosuppression"],"prefix":"10.1002","volume":"92","author":[{"given":"Jay J.","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Biology, Viral Immunology Center Georgia State University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica 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