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We collected nasopharyngeal specimens from 282 children aged \u22645 years with acute respiratory tract infection (ARI) during 2005 to 2006 in one of the largest Brazilian slums. We conducted real\u2010time reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) for 16 respiratory viruses, nested RT\u2010PCR\u2010based typing of rhinoviruses (HRVs), and collected clinical symptoms. Viruses were common causes of respiratory disease; with \u22651 virus being detected in 65.2% of patients. We detected 15 different viruses during 1 year with a predominance of HRV (33.0%) and human respiratory syncytial virus (hRSV, 12.1%) infections, and a high rate of viral coinfections (28.3%). We observed seasonality of hRSV, HRV and human coronavirus infections, more severe symptoms in hRSV and influenza virus (FLU) infections and prolonged circulation of seven HRV clusters likely representing distinct serotypes according to genomic sequence distances. Potentially unusual findings included the absence of human metapneumovirus detections and lack of typical FLU seasonal patterns, which may be linked to the population size and density of the slum. Nonetheless, most epidemiological patterns were similar to other studies globally, suggesting surprising similarities of virus\u2010associated ARI across highly diverse settings and a complex impact of population characteristics on respiratory virus epidemiology.<\/jats:p>","DOI":"10.1002\/jmv.25636","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T10:35:22Z","timestamp":1574764522000},"page":"1316-1321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Typical epidemiology of respiratory virus infections in a Brazilian slum"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-3308","authenticated-orcid":false,"given":"Luiz Gustavo Bentim","family":"G\u00f3es","sequence":"first","affiliation":[{"name":"Institute of Virology, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"},{"name":"Laborat\u00f3rio de Virologia Cl\u00ednica e Molecular, Departamento de Microbiologia \u2013 ICB\u2010II Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Melim","family":"Zerbinati","sequence":"additional","affiliation":[{"name":"Institute of Virology University of Bonn Medical Center Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Fumie","family":"Tateno","sequence":"additional","affiliation":[{"name":"Institute of Virology University of Bonn Medical Center Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Vieira","family":"de Souza","sequence":"additional","affiliation":[{"name":"Instituto de Ensino e Pesquisa Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Ebach","sequence":"additional","affiliation":[{"name":"Institute of Virology University of Bonn Medical Center Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Corman","sequence":"additional","affiliation":[{"name":"Institute of Virology, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"},{"name":"German Center for Infection Research (DZIF), associated partner site Charit\u00e9  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Moreira\u2010Filho","sequence":"additional","affiliation":[{"name":"Departmento de Pediatria Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison Luiz","family":"Durigon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Cl\u00ednica e Molecular, Departamento de Microbiologia \u2013 ICB\u2010II Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Vicente Ribeiro Ferreira","family":"da Silva Filho","sequence":"additional","affiliation":[{"name":"Instituto de Ensino e Pesquisa Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"},{"name":"Instituto da Crian\u00e7a Hospital das Cl\u00ednicas da FMUSP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-0232","authenticated-orcid":false,"given":"Jan Felix","family":"Drexler","sequence":"additional","affiliation":[{"name":"Institute of Virology, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"},{"name":"German Center for Infection Research (DZIF), associated partner site Charit\u00e9  Berlin Germany"},{"name":"Martsinovsky Institute of Medical Parasitology, Tropical and Vector\u2010Borne Diseases Sechenov University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00170-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00037-07"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2018.01.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2013.04.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2275-5"},{"key":"e_1_2_6_7_1","unstructured":"UN\u2010HABITAT.The challenge of slums: global\u00a0report on human settlements 2003. 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