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Here we target individuals with a high frequency of animal exposure in Vietnam. Three\u2010year community\u2010based surveillance was conducted in Vietnam during 2013\u20102016. We enrolled a total of 581 individuals (animal\u2010raising farmers, slaughterers, animal\u2010health workers, and rat traders), and utilized reverse transcription\u2010polymerase chain reaction to detect 15 common respiratory viruses in pooled nasal\u2010throat swabs collected at baseline or acute respiratory disease episodes. A respiratory virus was detected in 7.9% (58 of 732) of baseline samples, and 17.7% (136 of 770) of disease episode samples (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), with enteroviruses (EVs), rhinoviruses and influenza A virus being the predominant viruses detected. There were temporal and spatial fluctuations in the frequencies of the detected viruses over the study period, for example, EVs and influenza A viruses were more often detected during rainy seasons. We reported the detection of common respiratory viruses in individuals with a high frequency of animal exposure in Vietnam, an emerging infectious disease hotspot. 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