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In a cross\u2010sectional study, HSV\u20102 antibodies, HSV\u20102 DNA, and HR\u2010HPV DNA were quantified. Significant differences in HSV\u20102 seroprevalence and HSV\u20102 active infection rates were found between negative and positive HR\u2010HPV cases. HSV\u20102 seroprevalence was 28.15% and 16.1% (<jats:italic>P<\/jats:italic>\u2009=\u2009.0001), while HSV\u20102 active infection rates were 6.83% and 0.62% (<jats:italic>P<\/jats:italic>\u2009=\u2009.001) for positive and negative HR\u2010HPV groups, respectively. The risk of HSV\u20102 seropositivity was 1.7 times greater for HR\u2010HPV\u2010positive cases (<jats:italic>P<\/jats:italic>\u2009=\u2009.02). Similarly, HR\u2010HPV\u2010positive cases were nine times more likely to have an HSV\u20102 active infection than HR\u2010HPV\u2010negative cases (<jats:italic>P<\/jats:italic>\u2009=\u2009.03). High HSV\u20102\/h\u2010HPV coinfection rates were observed among women recruited from public gynecology and colposcopy services. The main factors related to an HSV\u20102 active infection are a history of risky sexual behavior and HR\u2010HPV infection. The prevalence of HSV\u20102 active infection among positive HR\u2010HPV subjects indicate that these infections constitute an important group of STIs in Mexico.<\/jats:p>","DOI":"10.1002\/jmv.25668","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T08:34:36Z","timestamp":1578731676000},"page":"1246-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence of active infection by herpes simplex virus type 2 in patients with high\u2010risk human papillomavirus infection: A cross\u2010sectional study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-4462","authenticated-orcid":false,"given":"M.","family":"Bahena\u2010Rom\u00e1n","sequence":"first","affiliation":[{"name":"Direcci\u00f3n de Infecciones Cr\u00f3nicas y C\u00e1ncer, Centro de Investigaci\u00f3n sobre Enfermedades Infecciosas, Instituto Nacional de Salud P\u00fablica (INSP)  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2383-7930","authenticated-orcid":false,"given":"M. A.","family":"S\u00e1nchez\u2010Alem\u00e1n","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Innovaci\u00f3n y Vigilancia de Enfermedades Infecciosas. Centro de Investigaci\u00f3n sobre Enfermedades Infecciosas, INSP  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3275-5526","authenticated-orcid":false,"given":"C. 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