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In recent decades, many studies that have evaluated the role of HCMV in inflammation and malignancies, especially in high\u2010grade gliomas, have reported inconsistent results. Thus, this study was conducted to analyze 97 primary gliomas for human CMV UL83 gene and protein through TaqMan real\u2010time polymerase chain reaction and immunohistochemistry, respectively. The results were positive for the UL83 gene and pp65 protein in 71% and 24% of samples, respectively. The frequency of HCMV was significantly higher in glioblastomas than other glioma grades (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01 and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05 for the UL83 gene and protein, respectively). In addition, the association between the prevalence of HCMV and aging strengthened the virus reactivation hypothesis in gliomas. In conclusion, a high frequency of HCMV infection was found in gliomas that correlated with tumor aggressiveness and age. This study recommends a thorough investigation to determine HCMV infection in gliomas to improve the existing knowledge of its role\u00a0in glial tumors, its prognostic value, and possible efficient antiviral target therapy.<\/jats:p>","DOI":"10.1002\/jmv.25673","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T08:05:34Z","timestamp":1579161934000},"page":"1266-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-7726","authenticated-orcid":false,"given":"Faezeh","family":"Maleki","sequence":"first","affiliation":[{"name":"Human Viral Vaccine Department Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO) Karaj Alborz Province 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