{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:31:37Z","timestamp":1792114297681,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate and analyze the relevant risk factors for bronchiolitis obliterans (BO) in children with severe adenovirus pneumonia, a retrospective study of children with severe adenovirus pneumonia was performed in 34 cases that developing BO and 105 cases not developing BO in Children's hospital of Chongqing Medical University from January 2015 to February 2019. The multivariate logistic regression analysis was used to identify factors which were significantly associated with development of BO after the univariate analysis, and receiver operating characteristic (ROC) curve analysis was performed to find out the cut\u2010off value for the significant relevant factors. A nonlinear dose\u2010response relationship between risk factors and the risk of BO was assessed by restricted cubic spline model. Three factors were independently associated with development of BO, which were length of fever (OR 1.129, 95% CI 1.033\u20101.234), dyspnea (OR 3.922, 95% CI 1.060\u201014.514) and invasive mechanical ventilation (OR 6.861, 95% CI 1.854\u201025.387). The cut\u2010off value of length of fever were 10.5 days. A linear dose\u2010response relationship between length of fever and occurrence of BO was observed (<jats:italic>P<\/jats:italic>\u2009=\u2009.57 for nonlinearity). Children with severe adenovirus pneumonia who have a longer duration of fever (especially more than 10.5 days), have dyspnea or require invasive mechanical ventilation in the acute phase are more likely to develop BO.<\/jats:p>","DOI":"10.1002\/jmv.25703","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T10:59:40Z","timestamp":1582023580000},"page":"3093-3099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Risk factors for the development of bronchiolitis obliterans in children with severe adenovirus pneumonia: A retrospective study with dose\u2010response analysis"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1742-7081","authenticated-orcid":false,"given":"Linping","family":"Zhong","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Pediatrics, Department of Respiratory Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation base of Child development and Critical Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilei","family":"Lin","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Pediatrics, Department of Respiratory Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation base of Child development and Critical Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Dai","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Pediatrics, 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