{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:01:55Z","timestamp":1790182915131,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To reconstruct the evolutionary dynamics of the 2019 novel\u2010coronavirus recently causing an outbreak in Wuhan, China, 52 SARS\u2010CoV\u20102 genomes available on 4 February 2020 at Global Initiative on Sharing All Influenza Data were analyzed. The two models used to estimate the reproduction number (coalescent\u2010based exponential growth and a birth\u2010death skyline method) indicated an estimated mean evolutionary rate of 7.8\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    subs\/site\/year (range, 1.1\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    \u201015\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    ) and a mean tMRCA of the tree root of 73 days. The estimated\n                    <jats:italic>R<\/jats:italic>\n                    value was 2.6 (range, 2.1\u20105.1), and increased from 0.8 to 2.4 in December 2019. The estimated mean doubling time of the epidemic was between 3.6 and 4.1 days. This study proves the usefulness of phylogeny in supporting the surveillance of emerging new infections even as the epidemic is growing.\n                  <\/jats:p>","DOI":"10.1002\/jmv.25723","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T06:24:18Z","timestamp":1582611858000},"page":"675-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["Early phylogenetic estimate of the effective reproduction number of SARS\u2010CoV\u20102"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3174-5721","authenticated-orcid":false,"given":"Alessia","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \"L. Sacco\" University of Milan  Milano Italy"},{"name":"Coordinated Research Center \"EpiSoMI\" University of Milan  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Bergna","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \"L. Sacco\" University of Milan  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Acciarri","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \"L. Sacco\" University of Milan  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-6215","authenticated-orcid":false,"given":"Massimo","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \"L. Sacco\" University of Milan  Milano Italy"},{"name":"Coordinated Research Center \"EpiSoMI\" University of Milan  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-2915","authenticated-orcid":false,"given":"Gianguglielmo","family":"Zehender","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \"L. Sacco\" University of Milan  Milano Italy"},{"name":"Coordinated Research Center \"EpiSoMI\" University of Milan  Milano Italy"},{"name":"Romeo ed Enrica Invernizzi Pediatric Research Center University of Milan  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104212"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msn083"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss075"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a003872"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss084"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058321"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207965110"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2004.06.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086616"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306742"},{"issue":"2001","key":"e_1_2_8_15_1","first-page":"2025","article-title":"Transmission dynamics of 2019 novel coronavirus (2019\u2010nCoV)","volume":"2020","author":"Liu T","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11090814"},{"key":"e_1_2_8_17_1","article-title":"Temporal variations in the effective reproduction number of the 2014 west Africa ebola outbreak","volume":"6","author":"Towers S","year":"2014","journal-title":"PLoS Currents"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020388"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.050"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:25:27Z","timestamp":1693985127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/jmv.25723"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25723","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.02.19.20024851","asserted-by":"object"}]},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,3]]},"assertion":[{"value":"2020-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}