{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:00:38Z","timestamp":1792684838554,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Following the severe acute respiratory syndrome coronavirus (SARS\u2010CoV) and Middle East respiratory syndrome coronavirus (MERS\u2010CoV), another highly pathogenic coronavirus named SARS\u2010CoV\u20102 (previously known as 2019\u2010nCoV) emerged in December 2019 in Wuhan, China, and rapidly spreads around the world. This virus shares highly homological sequence with SARS\u2010CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID\u201019) with clinical symptoms similar to those reported for SARS\u2010CoV and MERS\u2010CoV. The most characteristic symptom of patients with COVID\u201019 is respiratory distress, and most of the patients admitted to the intensive care could not breathe spontaneously. Additionally, some patients with COVID\u201019 also showed neurologic signs, such as headache, nausea, and vomiting. Increasing evidence shows that coronaviruses are not always confined to the respiratory tract and that they may also invade the central nervous system inducing neurological diseases. The infection of SARS\u2010CoV has been reported in the brains from both patients and experimental animals, where the brainstem was heavily infected. Furthermore, some coronaviruses have been demonstrated able to spread via a synapse\u2010connected route to the medullary cardiorespiratory center from the mechanoreceptors and chemoreceptors in the lung and lower respiratory airways. Considering the high similarity between SARS\u2010CoV and SARS\u2010CoV2, it remains to make clear whether the potential invasion of SARS\u2010CoV2 is partially responsible for the acute respiratory failure of patients with COVID\u201019. Awareness of this may have a guiding significance for the prevention and treatment of the SARS\u2010CoV\u20102\u2010induced respiratory failure.<\/jats:p>","DOI":"10.1002\/jmv.25728","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T05:52:46Z","timestamp":1582782766000},"page":"552-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1546,"title":["The neuroinvasive potential of SARS\u2010CoV2 may play a role in the respiratory failure of COVID\u201019 patients"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-9829","authenticated-orcid":false,"given":"Yan\u2010Chao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine Jilin University Changchun Jilin 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