{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:09Z","timestamp":1740104169709,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Jiangmen is one of the Guangdong\u2010Hong Kong\u2010Macao Greater Bay Areas with frequent commercial intercourse, which is responsible for human immunodeficiency virus type 1 (HIV\u20101) rapid circulation and genetic evolution for recent years. As a novel HIV\u20101 second\u2010generation recombinant was previously reported in Jiangmen but the systematic molecular epidemiological investigation was still unknown. A retrospective study on HIV\u20101 genotypic characteristics and the emergence of transmitted drug resistance in this region was necessary. A total of 224 newly diagnosed HIV\u2010positive cases were randomly selected in Jiangmen City of Guangdong Province between 2018 and 2019. The partial <jats:italic>gag<\/jats:italic> (1080\u2009bp), <jats:italic>pol<\/jats:italic> (840\u2009bp), and <jats:italic>env<\/jats:italic> (460\u2009bp) genes were amplified using nested polymerase chain reaction followed by sequencing. The phylogenetic and recombination analysis as well as HIV\u20101 drug resistance were performed to surveillance. Sexual transmission was determined to be the major risk factor in Jiangmen. Phylogenetic analysis detected the genotypic distribution as follows: CRF01_AE (36.65%,70 of 191), CRF07_BC (32.46%, 62 of 191), CRF08_BC (4.71%, 9 of 191), CRF55_01B (5.24%, 10 of 191), CRF59_01B (3.14%, 6 of 191), subtype B (4.71%, 9 of 191), subtype C (1.05%, 2 of 191) as well as unique recombinant forms (12.04%, 23 of 191) consisted of seven recombinant patterns, which originated from multiple regions of China. Low\u2010level prevalence of Surveillance Drug Resistance Mutations (2.1%) were predicted but drug\u2010resistant mutations showed at a high level (15.4%) especially mutations in RT gene at position 179 were found to be the most frequent in the therapy\u2010na\u00efve population. Our study highlighted the critical importance of monitoring the emerge of recombinant strains among newly diagnosed HIV\u20101 individuals along with drug resistance regularly to prevent multi\u2010channel introduction and breakout of new HIV strains.<\/jats:p>","DOI":"10.1002\/jmv.25741","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T06:45:07Z","timestamp":1583131507000},"page":"3209-3218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["HIV\u20101 genetic diversity and transmitted drug resistance among newly diagnosed HIV\u20101 individuals in Jiangmen, China"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6684-276X","authenticated-orcid":false,"given":"Xin","family":"Guan","sequence":"first","affiliation":[{"name":"School of Public Health, Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Han","sequence":"additional","affiliation":[{"name":"School of Public Health, Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiju","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangmen Center for Disease Control and Prevention  Jiangmen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangmen Center for Disease Control and Prevention  Jiangmen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Public Health, Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Public Health, Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization. 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