{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:28:08Z","timestamp":1792286888255,"version":"4.4.0"},"reference-count":92,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T00:00:00Z","timestamp":1585440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    By 27 February 2020, the outbreak of coronavirus disease 2019 (COVID\u201019) caused 82\u2009623 confirmed cases and 2858 deaths globally, more than severe acute respiratory syndrome (SARS) (8273 cases, 775 deaths) and Middle East respiratory syndrome (MERS) (1139 cases, 431 deaths) caused in 2003 and 2013, respectively. COVID\u201019 has spread to 46 countries internationally. Total fatality rate of COVID\u201019 is estimated at 3.46% by far based on published data from the Chinese Center for Disease Control and Prevention (China CDC). Average incubation period of COVID\u201019 is around 6.4 days, ranges from 0 to 24 days. The basic reproductive number (\n                    <jats:italic>\n                      R\n                      <jats:sub>0<\/jats:sub>\n                    <\/jats:italic>\n                    ) of COVID\u201019 ranges from 2 to 3.5 at the early phase regardless of different prediction models, which is higher than SARS and MERS. A study from China CDC showed majority of patients (80.9%) were considered asymptomatic or mild pneumonia but released large amounts of viruses at the early phase of infection, which posed enormous challenges for containing the spread of COVID\u201019. Nosocomial transmission was another severe problem. A total of 3019 health workers were infected by 12 February 2020, which accounted for 3.83% of total number of infections, and extremely burdened the health system, especially in Wuhan. Limited epidemiological and clinical data suggest that the disease spectrum of COVID\u201019 may differ from SARS or MERS. We summarize latest literatures on genetic, epidemiological, and clinical features of COVID\u201019 in comparison to SARS and MERS and emphasize special measures on diagnosis and potential interventions. This review will improve our understanding of the unique features of COVID\u201019 and enhance our control measures in the future.\n                  <\/jats:p>","DOI":"10.1002\/jmv.25748","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T06:18:16Z","timestamp":1583389096000},"page":"568-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1046,"title":["Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID\u201019) implicate special control measures"],"prefix":"10.1002","volume":"92","author":[{"given":"Yixuan","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Human Virology and Oncology Shantou University Medical College  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Human Virology and Oncology 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