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In the absence of longitudinal human tissue samples at defined time points, we have characterized changes in tamarins. As early as 2 weeks post\u2010infection histological changes were noticeable, and these were established in all animals by 6 weeks. Despite high levels of liver\u2010associated viral RNA, there was reversal of hepatic damage on clearance of peripheral virus though fibrosis was demonstrated in four tamarins. Notably, viral RNA burden in the liver dropped to near undetectable or background levels in all animals which underwent a second viral challenge, highlighting the efficacy of the immune response in removing foci of replication in the liver. These data add to the knowledge of GBV\u2010B infection in New World primates which can offer attractive systems for the testing of prophylactic and therapeutic treatments and the evaluation of their utility in preventing or reversing liver pathology.<\/jats:p>","DOI":"10.1002\/jmv.25769","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T13:57:04Z","timestamp":1584453424000},"page":"3584-3595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of hepatic pathology in GBV\u2010B\u2010infected red\u2010bellied tamarins (<i>Saguinus labiatus<\/i>)"],"prefix":"10.1002","volume":"92","author":[{"given":"Jessica M.","family":"Dale","sequence":"first","affiliation":[{"name":"Division of Virology National Institute for Biological Standards and Control, Medicine and Healthcare products Regulatory Agency  Blanche Lane, South Mimms, Potters Bar Hertfordshire 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