{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:14:31Z","timestamp":1790468071154,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T00:00:00Z","timestamp":1585440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 26460459"],"award-info":[{"award-number":["JP 26460459"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Koilocytes are considered a common cytopathological effect in patients with human papillomavirus (HPV) infection. Thus, we aimed to elucidate whether koilocytes are common to all HPV infections. Liquid\u2010based cytology samples from 651 patients with abnormal Papanicolaou (Pap) test results were used to analyze the presence of koilocytes and HPV genotype. HPV genotype was determined in complete liquid cytology samples and microdissected cell samples from Pap smear slides using the uniplex E6\/E7 polymerase chain reaction method, which can detect 39 mucosal HPV genotypes. Koilocytes were found in 29.3% (191) of all patients. Logistical regression analysis of diverse HPV genotypes revealed that infections with low\u2010risk HPV types (HPV\u20106b, HPV\u201040, HPV\u201042, HPV\u201061, HPV\u201074, HPV\u201089, and HPV\u201090), probably high\u2010risk HPV types (HPV\u201053 and HPV\u201066), and high\u2010risk types (HPV\u201039 and HPV\u201056) were significantly associated with the presence of koilocytes. However, HPV\u201016, HPV\u201018, and HPV\u201052, which have higher oncogenic potential, were not found to be associated with koilocytes. These results were confirmed by HPV genotyping using microdissected koilocytes in 27 patients.Most common high\u2010risk types belonging to \u03b1\u20109 and \u03b1\u20107 genotypes appear to rarely induce koilocytic changes. Therefore, koilocytes may provide additional useful information for predicting the risk of progression to high\u2010grade lesions.<\/jats:p>","DOI":"10.1002\/jmv.25775","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:02:37Z","timestamp":1584619357000},"page":"3766-3773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Koilocytic changes are not elicited by human papillomavirus genotypes with higher oncogenic potential"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6152-3217","authenticated-orcid":false,"given":"Mitsuaki","family":"Okodo","sequence":"first","affiliation":[{"name":"Department of Medical Technology, Faculty of Health Sciences Kyorin University  Tokyo 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 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Genki Plaza Medical Center for Health Care  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Health Sciences Kyorin University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizue","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Gynecology Genki Plaza Medical Center for Health Care  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-844X","authenticated-orcid":false,"given":"Toshiyuki","family":"Sasagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University  Ishikawa 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