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ACE2 is a crucial component of the renin\u2010angiotensin system (RAS). The classical RAS ACE\u2010Ang II\u2010AT1R regulatory axis and the ACE2\u2010Ang 1\u20107\u2010MasR counter\u2010regulatory axis play an essential role in maintaining homeostasis in humans. ACE2 is widely distributed in the heart, kidneys, lungs, and testes. ACE2 antagonizes the activation of the classical RAS system and protects against organ damage, protecting against hypertension, diabetes, and cardiovascular disease. Similar to SARS\u2010CoV, SARS\u2010CoV\u20102 also uses the ACE2 receptor to invade human alveolar epithelial cells. Acute respiratory distress syndrome (ARDS) is a clinical high\u2010mortality disease, and ACE2 has a protective effect on this type of acute lung injury. Current research shows that the poor prognosis of patients with COVID\u201019 is related to factors such as sex (male), age (&gt;60 years), underlying diseases (hypertension, diabetes, and cardiovascular disease), secondary ARDS, and other relevant factors. Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein\u2010based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID\u201019 in the future.<\/jats:p>","DOI":"10.1002\/jmv.25785","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T06:01:30Z","timestamp":1585375290000},"page":"726-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":378,"title":["Organ\u2010protective effect of angiotensin\u2010converting enzyme 2 and its effect on the prognosis of COVID\u201019"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-614X","authenticated-orcid":false,"given":"Hao","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and the Center for Liver Diseases Peking University First Hospital  Beijing 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