{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:06:41Z","timestamp":1791356801788,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute respiratory disease caused by 2019 novel coronavirus (2019\u2010nCoV) has rapidly spread throughout China. Children and adults show a different clinical course. The purpose of the current study is to comparatively analyze the clinical characteristics of 2019\u2010nCoV infection in children and adults and to explore the possible causes for the discrepancies present. The medical records of 25 adults and 7 children confirmed cases of 2019\u20102019\u2010nCoV acute respiratory diseases were reviewed retrospectively. All children were family clusters. The total adult patients were differentiated into the local residents of Wuhan, a history of travel to Wuhan and direct contact with people from Wuhan. The numbers were 14 (56%), 10 (40%), and 1 (4%), respectively. The median incubation period of children and adults was 5 days (ranged, 3\u201012 days) and 4 days (ranged, 2\u201012 days), respectively. Diarrhoea and\/or vomiting (57.1%) were demic by World Health Organiza more common in children, whereas for adults it was myalgia or fatigue (52%). On admission, the percentage of children having pneumonia (5%, 71.4%) was roughly the same as adults (20%, 80%). A total of 20% of adults had leucopoenia, but leukocytosis was more frequently in children (28.6%, <jats:italic>P<\/jats:italic>=.014). A higher number of children had elevated creatine kinase isoenzyme (57.1% vs 4%, <jats:italic>P<\/jats:italic>=.004). Antiviral therapy was given to all adult patients but to none of the children. In summary, knowledge of these differences between children and adults will not only be helpful for the clinical diagnosis of\u00a02019\u2010nCoV disease, but also for a future discussion on age\u2010specific coronavirus infection.<\/jats:p>","DOI":"10.1002\/jmv.25835","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T10:41:15Z","timestamp":1586169675000},"page":"1596-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["A comparative\u2010descriptive analysis of clinical characteristics in 2019\u2010coronavirus\u2010infected children and adults"],"prefix":"10.1002","volume":"92","author":[{"given":"Ya\u2010nan","family":"Han","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan\u2010wei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010na","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010xia","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010ming","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Radiology Xi'an Eighth Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of NICU Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-301X","authenticated-orcid":false,"given":"Ying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_3_1","unstructured":"WHO main website.https:\/\/www.who.int. (Accessed 29 February 2020)."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12020135"},{"key":"e_1_2_10_6_1","unstructured":"WHO main website.https:\/\/www.who.int. (Accessed 5 February 2020)."},{"key":"e_1_2_10_7_1","unstructured":"Chinese Center For Disease Control and Prevention main website.http:\/\/www.nhc.gov.cn. (Accessed 28 February 2020)."},{"key":"e_1_2_10_8_1","article-title":"First case of neonate infected with novel coronavirus pneumonia in China. Chinese","volume":"58","author":"Zeng LK","year":"2020","journal-title":"J Pediatr"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"145","article-title":"The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID\u201019) in China","volume":"41","author":"Epidemiology group, New coronavirus pneumonia emergency response mechanism, Chinese CDC","year":"2020","journal-title":"Chin J Epidemiol"},{"key":"e_1_2_10_10_1","article-title":"Frist case of severe childhood novel coronavirus pneumonia in China","volume":"58","author":"Chen F","year":"2020","journal-title":"Chinese J Pediatr"},{"key":"e_1_2_10_11_1","unstructured":"YangY LQ LiuM et al.Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. MexRxiv preprint2020."},{"key":"e_1_2_10_12_1","unstructured":"Diagnosis and Treatment of Pneumonia Caused by 2019\u2010nCoV (version 5).http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202002\/3b09b894ac9b4204a79db5b8912d4440.shtml. (Accessed 5 February 2020)."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-020-00345-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2131"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_10_18_1","article-title":"Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue","author":"Shen KL","year":"2020","journal-title":"World J Pediatr"},{"issue":"2020","key":"e_1_2_10_19_1","article-title":"Manifestations of digestive system in hospitalized patients with novel coronavirus pneumonia in Wuhan, China: a single\u2010center, descriptive study","volume":"40","author":"Fang D","year":"2020","journal-title":"Chin J Dig"},{"key":"e_1_2_10_20_1","article-title":"The digestive system is a potential route of 2019\u2010nCoV infection: a bioinformatics analysis based on single\u2010cell transcriptomes","author":"Zhang H","year":"2020","journal-title":"BioRxiv"},{"key":"e_1_2_10_21_1","article-title":"Profiling ACE2 expression in colon tissue of healthy adults and colorectal cancer patients by single\u2010cell transcriptome analysis","author":"Chen H","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_10_22_1","unstructured":"National Recommendations for Diagnosis and Treatment of pneumonia caused by 2019\u2010nCoV (the 4th edition). National Health Commission and National Administrative Office of Chinese Tradition Medicine.https:\/\/www.nhc.gov.cn\/xcs\/zheng_cwj\/202001\/42945_63ed3_5b432_09b31_739bd_0785e_67\/files\/7a930_91112_67475_a99d4_30696_2c8bf_78.pdf. (Accessed 29 January 2020)."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01472"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.2003.012658"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taaa020"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25763"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:33:28Z","timestamp":1693884808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/jmv.25835"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25835","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,17]]},"assertion":[{"value":"2020-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}