{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:59:03Z","timestamp":1754488743181,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Nanjing Department of Health","award":["YKK18176"],"award-info":[{"award-number":["YKK18176"]}]},{"name":"Humanities and Social Sciences of Ministry of Education Planning Fund of China","award":["16YJA840014"],"award-info":[{"award-number":["16YJA840014"]}]},{"name":"Medical Science and Technology Development Foundation, Nanjing Department of Health","award":["YKK18176"],"award-info":[{"award-number":["YKK18176"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To understand the epidemiology, evolutionary and transmission characteristics of HIV\u20101 CRF07_BC in Nanjing, China. One hundred and fifty\u2010nine patients with HIV\u20101 CRF07_BC were recruited. DNA sequencing, phylogenetic analysis, and molecular transmission cluster analysis were conducted to determine the molecular epidemiology and evolutionary characteristics. Of these HIV\u20101\u2010infected patients, 95.6% were male, and men who sex with men (76.7%) were the main transmission route. Only 34.0% of these cases were born in Nanjing, and most of them (64.8%) reported having multiple sex partners in the last 6 months. The maximum likelihood phylogenetic analyses of HIV\u20101 CRF07_BC revealed two lineages. Overall, 67.3% of Nanjing sequences were connected to at least one other individual distributed in 11 clusters, and the average degree was 21.2 with range (1\u2010178). The clustered patients were more likely to be male. The time to a most recent common ancestor for the early HIV\u20101 CRF07_BC circulating in Nanjing was estimated to be 1998.71[1997.36\u20102001.07]. The mean estimated evolutionary rate for the epidemic cluster was slightly lower at 2.38[2.12\u20102.65]\u2009\u2009\u00d7\u2009\u200910<jats:sup>\u22123<\/jats:sup> per site per year with the relaxed exponential clock model. HIV\u20101 CRF07_BC was transmitted into Nanjing more than 20 years ago from Yunnan and has become one of the most predominant subtypes with a higher evolutionary rate than before.<\/jats:p>","DOI":"10.1002\/jmv.25854","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T10:50:23Z","timestamp":1586515823000},"page":"3237-3245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The evolutionary and transmission characteristic of HIV\u20101 CRF07_BC in Nanjing, Jiangsu"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0769-5805","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoshan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lung Transplant Center The Affiliated Wuxi People's Hospital of Nanjing Medical University  Wuxi Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-7916","authenticated-orcid":false,"given":"You","family":"Ge","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason J.","family":"Ong","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health  Melbourne Australia"},{"name":"Central Clinical School Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing Municipal Center for Disease Control and Prevention  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Dong","sequence":"additional","affiliation":[{"name":"Nanjing Municipal Center for Disease Control and Prevention  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Chu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha Hussein","family":"Musa","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Qian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health  Melbourne Australia"},{"name":"Central Clinical School Monash University  Melbourne Australia"},{"name":"Department of Epidemiology and Biostatistics, College of Public Health Zhengzhou University  Zhengzhou Henan China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Xi'an Jiaotong University Health Science Center  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingmin","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health Southeast University, Ministry of Education  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"210","article-title":"Molecular epidemiology of HIV\u20101 variants in the global AIDS pandemic: an update","volume":"7","author":"Thomson MM","year":"2005","journal-title":"AIDS Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19279"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06573-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/513437"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.685-695.2003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/088922202320567879"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.0196"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.1051"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052373"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047289"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2019.0051"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2018.0266"},{"key":"e_1_2_9_14_1","article-title":"Characterization of a novel HIV\u20101 recombinant form (CRF01_AE\/CRF07_BC\/CRF08_BC) identified from Guangxi, China","author":"Liang B","year":"2019","journal-title":"AIDS Res Hum Retroviruses"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2019.0141"},{"issue":"8","key":"e_1_2_9_16_1","first-page":"1202","article-title":"Epidemiological characteristics of HIV infection among population aged 15\u201024 years from 2011 to 2016","volume":"39","author":"Yuanyuan Xu","year":"2018","journal-title":"Chinese J School Health"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-019-1162-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000067"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24223"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102258"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2019.104038"},{"key":"e_1_2_9_22_1","first-page":"221","article-title":"The use of CLUSTAL W and CLUSTAL X for multiple sequence alignment","volume":"132","author":"Aiyar A.","year":"2000","journal-title":"Methods Mol Biol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg103"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msy096"},{"issue":"12","key":"e_1_2_9_25_1","first-page":"1278","article-title":"Analysis on the transmission characteristics of newly reported human immunodeficiency virus\/acquired immunodeficiency syndrome cases based on the molecular transmission network in Huzhou, Zhejiang, 2017","volume":"53","author":"Chen WJ","year":"2019","journal-title":"Chin J Preventive Med"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.23.11367-11376.2000"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2019.104038"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002729"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X17666190530081355"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2016.0029"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.10.035"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16708"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009826"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2008.0250"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2378-z"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2007.0058"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2019.0199"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25072"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0124"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2016-053085"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.25854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.25854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.25854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:48:44Z","timestamp":1693226924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.25854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/jmv.25854"],"URL":"https:\/\/doi.org\/10.1002\/jmv.25854","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2020,6,19]]},"assertion":[{"value":"2020-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}