{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:53:31Z","timestamp":1790488411268,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novel Coronavirus Pneumonia Emergency Project of Hunan Provincial Science and Technology Department","award":["2020SK3018"],"award-info":[{"award-number":["2020SK3018"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>COVID\u201019 has developed into a worldwide pandemic; early identification of severe illness is critical for controlling it and improving the prognosis of patients with limited medical resources. The present study aimed to analyze the characteristics of severe COVID\u201019 and identify biomarkers for differential diagnosis and prognosis prediction. In total, 27 consecutive patients with COVID\u201019 and 75 patients with flu were retrospectively enrolled. Clinical parameters were collected from electronic medical records. The disease course was divided into four stages: initial, progression, peak, and recovery stages, according to computed tomography (CT) progress. to mild COVID\u201019, the lymphocytes in the severe COVID\u201019 progressively decreased at the progression and the peak stages, but rebound in the recovery stage. The levels of C\u2010reactive protein (CRP) in the severe group at the initial and progression stages were higher than those in the mild group. Correlation analysis showed that CRP (<jats:italic>R<\/jats:italic>\u2009=\u2009.62; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), erythrocyte sedimentation rate (<jats:italic>R<\/jats:italic>\u2009=\u2009.55; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and granulocyte\/lymphocyte ratio (<jats:italic>R<\/jats:italic>\u2009=\u2009.49; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) were positively associated with the CT severity scores. In contrast, the number of lymphocytes (<jats:italic>R<\/jats:italic>\u2009=\u2009\u2212.37; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) was negatively correlated with the CT severity scores. The receiver\u2010operating characteristic analysis demonstrated that area under the curve of CRP on the first visit for predicting severe COVID\u201019 was 0.87 (95% CI 0.10\u20131.00) at 20.42 mg\/L cut\u2010off, with sensitivity and specificity 83% and 91%, respectively. CRP in severe COVID\u201019 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.25871","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T12:09:49Z","timestamp":1586779789000},"page":"856-862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":403,"title":["C\u2010reactive protein correlates with computed tomographic findings and predicts severe COVID\u201019 early"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-667X","authenticated-orcid":false,"given":"Chaochao","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxia","family":"Shi","sequence":"additional","affiliation":[{"name":"Radiology Department Hunan Provincial People's Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qionghui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Changsha First Hospital Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Changsha First Hospital Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Yueyang second People's Hospital Yueyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-4524","authenticated-orcid":false,"given":"Xiaosong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Research, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,25]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Clinical characteristics of coronavirus disease 2019 in China [published online ahead of print February 28, 2020]","author":"Guan W","journal-title":"N Engl J Med"},{"key":"e_1_2_9_3_1","article-title":"Critical care crisis and some recommendations during the COVID\u201019 epidemic in China [published online ahead of print March 2, 2020]","author":"Xie J","journal-title":"Intensive Care Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.02.016"},{"key":"e_1_2_9_6_1","unstructured":"Diagnosis and treatment protocols of pneumonia caused by new coronavirus (trial version 7 revised edition).National Health Commission of the People's Republic of China.http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202003\/46c9294a7dfe4cef80dc7f5912eb1989\/files\/ce3e6945832a438eaae415350a8ce964.pdf. 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Clinical characteristics of deceased patients infected with SARS\u2010CoV\u20102 in Wuhan China (2\/24\/2020). 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