{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:14Z","timestamp":1790713394544,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As persistent carcinogenic human papillomavirus (HPV) infection is a prominent driver of cervical cancer, it is essential to explore HPV persistence and its associated factors for cancer screening and prevention. A retrospective cohort study was performed in outpatient women between March 2010 and 2019 in Heilongjiang, northeast China. HPV genotyping was performed by polymerase chain reaction\u2010membrane hybridization. An unconditional logistic regression model was used to analyze the association of factors with persistence. The overall prevalence of HPV at baseline was 27.1%, with a downward trend from 2010 to 2019 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u2009.0001). The most commonly observed high\u2010 and low\u2010risk HPVs were HPV16 (N\u2009=\u20091094, 5.9%) and HPV11 (N\u2009=\u2009596, 3.2%), respectively. The probabilities of 6\u2010month persistence were high for women infected with HPV16 (<jats:italic>P<\/jats:italic>\u2009=\u2009.0001), HPV58 (<jats:italic>P<\/jats:italic>\u2009=\u2009.018), and HPV53 (<jats:italic>P<\/jats:italic>\u2009=\u2009.014), as well as for women with multiple infections (<jats:italic>P<\/jats:italic>\u2009=\u2009.009), and those who were 51 to 60 years old (<jats:italic>P<\/jats:italic>\u2009=\u2009.004) or more than \u200960 years old (<jats:italic>P<\/jats:italic>\u2009=\u2009.007). The probabilities of 12\u2010month persistence were high for women infected with HPV53 (<jats:italic>P<\/jats:italic>\u2009=\u2009.017) and 51\u2010 to 60\u2010year\u2010old women (<jats:italic>P<\/jats:italic>\u2009=\u2009.044). HPV16 is the dominant HPV type in Heilongjiang. An age in the range of 51 to 60 years and infection with HPV53 is associated with HPV infection persistence in the Heilongjiang population.<\/jats:p>","DOI":"10.1002\/jmv.25899","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:04:25Z","timestamp":1587042265000},"page":"3784-3792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epidemiology and persistence of cervical human papillomavirus infection among outpatient women in Heilongjiang province: A retrospective cohort study"],"prefix":"10.1002","volume":"92","author":[{"given":"Jiaxin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Microbiology Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Obstetrics 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