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Thus, the search for effective therapeutic alternatives in the control of the limitations caused by this virus during the stages of evolution of the disease, is necessary, since they have a direct impact on the quality of life of the patients. The aim of the present study was to evaluate the efficacy of the in situ film precursor semisolid composition in the treatment of herpes simplex lesions in human HSV\u20101. Ninety\u2010eight (n\u2009=\u200998) patients with HSV\u20101 were used for this study. The initial exclusion criteria left 81 patients to be considered in the present study. Three applications were performed, the first at time zero (T0) and the other two at 8 and 16\u2009hours, after initial application (T8 and T16). Photographs were taken in the first appointment and 24 and 72\u2009hours after the last application. After the three periods, each patient received a total amount of 90\u2009mg of anesthetic and the prognosis of the patients was followed for 6 months and 1 year after the application. Frequency analysis showed that 40.3% of patients had remission of symptoms 24\u2009hours after the last application. For the present study, the film presented a positive therapeutic potential and an esthetic benefit that is absent in the current products (ointments and gels). The invent presents dosage convenience (only three applications in a 24\u2010hour period) and a low production cost, with a much shorter healing time than that reported using topical antiretrovirals.<\/jats:p>","DOI":"10.1002\/jmv.25982","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T12:57:40Z","timestamp":1588769860000},"page":"3638-3644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Local anesthetic improves individuals affected with herpes simplex type 1 labialis"],"prefix":"10.1002","volume":"92","author":[{"given":"Monica Danielle Ribeiro","family":"Bastos","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prothesis, School of Dentistry of Ribeirao Preto University of Sao Paulo Ribeirao Preto Sao Paulo 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