{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:17:34Z","timestamp":1783469854029,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although emerging data demonstrated mortality of young COVID\u201019 patients, no data have reported the risk factors of mortality for these young patients, and whether obesity is a risk for young COVID\u201019 patients remains unknown. We conducted a retrospective study including 13 young patients who died of COVID\u201019 and 40 matched survivors. Logistic regression was employed to characterize the risk factors of mortality in young obese COVID\u201019 patients. Most of the young deceased COVID\u201019 patients were mild cases at the time of admission, but the disease progressed rapidly featured by a higher severity of patchy shadows (100.00% vs 48.70%; <jats:italic>P<\/jats:italic>\u2009=\u2009.006), pleural thickening (61.50% vs 12.80%; <jats:italic>P<\/jats:italic>\u2009=\u2009.012), and mild pericardial effusion (76.90% vs 0.00%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Most importantly, the deceased patients manifested higher body mass index (odds ratio [OR]\u2009=\u20091.354; 95% confidence interval [CI]\u2009=\u20091.075\u20101.704; <jats:italic>P<\/jats:italic>\u2009=\u2009.010), inflammation\u2010related index C\u2010reactive protein (OR\u2009=\u20091.014; 95% CI\u2009=\u20091.003\u20101.025; <jats:italic>P<\/jats:italic>\u2009=\u2009.014), cardiac injury biomarker hs\u2010cTnI (OR\u2009=\u20091.420; 95% CI\u2009=\u20091.112\u20101.814; <jats:italic>P<\/jats:italic>\u2009=\u2009.005), and increased coagulation activity biomarker D\u2010dimer (OR\u2009=\u2009418.7; <jats:italic>P<\/jats:italic>\u2009=\u2009.047), as compared with that of survivors. Our data support that obesity could be a risk factor associated with high mortality in young COVID\u201019 patients, whereas aggravated inflammatory response, enhanced cardiac injury, and increased coagulation activity are likely to be the mechanisms contributing to the high mortality.<\/jats:p>","DOI":"10.1002\/jmv.26039","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T12:59:42Z","timestamp":1590065982000},"page":"2536-2542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Obesity predisposes to the risk of higher mortality in young COVID\u201019 patients"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-2456","authenticated-orcid":false,"given":"Fengqin","family":"Zhang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine Tongji Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tongji Medical College, Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Wei","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine Tongji Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Medical College, The Central Hospital of Wuhan Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Medical College, Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"The Outpatient Office, Tongji Medical College, Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Liu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine Tongji Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-5531","authenticated-orcid":false,"given":"Ronghui","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Pulmonary Hospital, Bao Feng Road, Qiao Kou District Wuhan, HuBei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Respiratory Diseases, Center for Biomedical Research, Tongji Hospital Research Building Tongji Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-6802","authenticated-orcid":false,"given":"Wenzhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tongji Medical College, Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_6_3_1","unstructured":"Johns Hopkins University.Coronavirus COVID\u201019 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU).https:\/\/coronavirus.jhu.edu\/map.html. 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