{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:13:43Z","timestamp":1773090823629,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI137822"],"award-info":[{"award-number":["AI137822"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI146226"],"award-info":[{"award-number":["AI146226"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM130555\u20106610"],"award-info":[{"award-number":["GM130555\u20106610"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>SARS\u2010CoV\u20102 is highly infectious, and infection by this virus results in COVID\u201019, manifesting predominantly symptoms in the lower respiratory system. Detection of viral genomic materials by RT\u2010PCR is the gold standard for diagnosis. Suspected COVID\u201019 patients who had a documented history of exposure and exhibited symptoms, but did not have positive PCR test results, were generally self\u2010quarantined with prescriptions aiming to help attenuate their symptoms. These prescriptions are however neither specific nor highly effective for COVID\u201019 treatment. Given the rapidly growing pandemic and the overwhelmed medical system, the number of self\u2010quarantined patients is increasing. There is an urgent need of alternative medicine to help patients relieve symptoms during self\u2010quarantine, and to potentially help increase their chances of survival and recovery from the infection. We report here a case of severe COVID\u201019 that never had a positive PCR test result during disease progression but was confirmed with antibody test post recovery. This patient was self\u2010quarantined and received diammonium glycyrrhizinate (DG), a steroid\u2010like molecule, in combination with vitamin C as alternative medicine. This patient went through severe COVID\u201019 but eventually recovered upon the implementation of this treatment regimen, suggesting potential therapeutic effects of DG as alternative medicine to help relieve COVID\u201019 symptoms.<\/jats:p>","DOI":"10.1002\/jmv.26064","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T08:21:19Z","timestamp":1590567679000},"page":"2200-2204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in nonhospitalized COVID\u201019 patients"],"prefix":"10.1002","volume":"92","author":[{"given":"Hong","family":"Ding","sequence":"first","affiliation":[{"name":"Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of anatomy School of Basic Medical Sciences, Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanye","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana Farber Cancer Institute  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-1131","authenticated-orcid":false,"given":"Weishan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana"},{"name":"Department of Microbiology &amp; Immunology College of Veterinary Medicine, Cornell University  Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb6105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1661-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"145","article-title":"The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID\u201019) in China","volume":"41","author":"Novel Coronavirus Pneumonia Emergency Response Epidemiology Team","year":"2020","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30185-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_9_9_1","article-title":"COVID\u201019 diagnostic process in mainland China: The math beyond pneumonia","author":"Wu F","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0308-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30317-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01009-2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-020-0628-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.05.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01185.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.07.004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","unstructured":"ZhuX ChenC YeD et al.Diammonium glycyrrhizinate upregulates PGC\u20101alpha and protects against Abeta1\u201042\u2010induced neurotoxicity.PLoS One.2012;7(4):e35823.","DOI":"10.1371\/journal.pone.0035823"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0493008"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.26064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.26064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.26064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T16:20:19Z","timestamp":1693844419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.26064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,5]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/jmv.26064"],"URL":"https:\/\/doi.org\/10.1002\/jmv.26064","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,5]]},"assertion":[{"value":"2020-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}