{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:05:23Z","timestamp":1774789523611,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701632"],"award-info":[{"award-number":["81701632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2017SF\u2010154"],"award-info":[{"award-number":["2017SF\u2010154"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) can lead to high morbidity and mortality, and genetic background plays an important role during the disease process. We investigated the association between the single\u2010nucleotide polymorphism (SNP) rs2564978 of the <jats:italic>CD55<\/jats:italic> gene and susceptibility to and severity of HFMD using the SNPs can multiple SNP typing methods. Soluble CD55 (sCD55) expression was significantly lower in the EV71 HFMD group than in the control group and lower in severe cases than in mild cases (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Moreover, <jats:italic>CD55<\/jats:italic> rs2564978 (C vs T OR\u2009=\u20091.300, 95% CI, 1.120\u20101.509) was associated with the risk of EV71 infection, and genotype TC was related to the severity of the infection (TC vs TT OR\u2009=\u20094.523, 95% CI, 2.033\u201010.066). Our results suggest that sCD55 expression and the <jats:italic>CD55<\/jats:italic> polymorphism rs2564978 may influence the susceptibility to and severity of EV71 infection.<\/jats:p>","DOI":"10.1002\/jmv.26088","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T17:41:50Z","timestamp":1590774110000},"page":"3119-3124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of gene polymorphisms of <i>CD55<\/i> with susceptibility to and severity of hand, foot, and mouth disease caused by enterovirus 71 in the Han Chinese population"],"prefix":"10.1002","volume":"92","author":[{"given":"Mei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-8647","authenticated-orcid":false,"given":"Hui\u2010Ling","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Department of Infectious Diseases Xi'an Children's Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Department of Infectious Diseases Xi'an Children's Hospital  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-5711","authenticated-orcid":false,"given":"Shuang\u2010Suo","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181a41d63"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3624-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25393"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212561200"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01117"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.11.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.139"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.10.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.848"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21216"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1844"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa3526"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis378"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix235"},{"key":"e_1_2_8_16_1","unstructured":"Ministry of Health of the People's Republic of China.Hand Foot and Mouth Disease Clinical Guide (2010 edition) (in Chinese)http:\/\/www.moh.gov.cn\/publicfiles\/business\/htmlfiles\/mohyzs\/s3586\/201004\/46884.htm. 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