{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:17:37Z","timestamp":1760015857356,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["DESP060001\u201001\u201001"],"award-info":[{"award-number":["DESP060001\u201001\u201001"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Cameroon, routine diagnosis of central nervous system (CNS) infections is based on the detection of bacteria, fungi, parasites, and mycobacteria in cerebrospinal fluids. Therefore, there is no data on viral etiologies of meningoencephalitis (ME) in the country. We aim to identify viral etiologies (herpesviruses and enteroviruses) of ME\u00a0in Cameroon, to provide useful information to physicians that will help improving management of ME. From February to May 2018, adult patients with clinical signs of ME in three referral hospitals in Yaounde were included. Detection of herpesviruses and enteroviruses was performed using reverse transcriptase polymerase chain reaction. <jats:italic>P<\/jats:italic> value of 5% was chosen as the threshold for statistical significance in statistical analyses. Eighty\u2010one patients were included and 15 (18.51%) were positive for herpesviruses. No enterovirus was detected. The most prevalent virus was Epstein\u2010Barr virus (8.6%) and most of herpesviruses were detected from human immunodefeciency virus (HIV)\u2010positive patients (86.7%). The overall mortality rate was high, 60.5% (49\/81) and analysis of risk factors showed that HIV\u2010positive status and altered state of consciousness were associated with higher risk of death (odds ratio [OR], 5.41; confidence interval [CI]: 1.91\u201016.88;\u00a0<jats:italic>P<\/jats:italic>\u2009=\u2009.002 and OR, 3.24; CI:\u00a01.11\u20100.13;\u00a0<jats:italic>P<\/jats:italic>\u2009=\u2009.036 respectively). We showed that herpesviruses are present in patients with ME symptoms in Yaounde and can be sometimes in coinfection with others common pathogens of CNS infections. There is therefore a need for increased clinician awareness and education regarding the diagnostic and management of CNS infections in Cameroon to limit unnecessary use of antibiotics.<\/jats:p>","DOI":"10.1002\/jmv.26109","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T17:03:03Z","timestamp":1591203783000},"page":"3843-3848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detection of herpesviruses and enteroviruses in patients with suspected infectious meningoencephalitis in three referral hospitals in Yaounde, Cameroon"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7449-5128","authenticated-orcid":false,"given":"Paul Alain","family":"Tagnouokam\u2010Ngoupo","sequence":"first","affiliation":[{"name":"Department of Virology Centre Pasteur of Cameroon  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roselyne","family":"Toby","sequence":"additional","affiliation":[{"name":"Infectious Disease Ward Yaounde Central Hospital  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Olivia","family":"Bomba Ebede","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur de Technologie M\u00e9dicale, Nkolondom University of Douala  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Kenmoe","sequence":"additional","affiliation":[{"name":"Department of Virology Centre Pasteur of Cameroon  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie Teclaire","family":"Ngo\u2010Malabo","sequence":"additional","affiliation":[{"name":"Department of Virology Centre Pasteur of Cameroon  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge Alain","family":"Sadeuh\u2010Mba","sequence":"additional","affiliation":[{"name":"Department of Virology Centre Pasteur of Cameroon  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magloire","family":"Biwole\u2010Sida","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaounde  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-6370","authenticated-orcid":false,"given":"Richard","family":"Njouom","sequence":"additional","affiliation":[{"name":"Department of Virology Centre Pasteur of Cameroon  Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.12.035"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.06.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.08.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111393"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003127"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2017.02.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23953"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-017-0150-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.05.031"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2009.03.027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003052"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2014.07.010"},{"issue":"4","key":"e_1_2_10_14_1","first-page":"373","article-title":"Retrospective 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