{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:06:32Z","timestamp":1790658392937,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ongoing outbreak of a new coronavirus (2019\u2010nCoV, or severe acute respiratory syndrome coronavirus 2 [SARS\u2010CoV\u20102]) has caused an epidemic of the acute respiratory syndrome known as coronavirus disease (COVID\u201019) in humans. SARS\u2010CoV\u20102 rapidly spread to multiple regions of China and multiple other countries, posing a serious threat to public health. The spike (S) proteins of SARS\u2010CoV\u20101 and SARS\u2010CoV\u20102 may use the same host cellular receptor, angiotensin\u2010converting enzyme 2 (ACE2), for entering host cells. The affinity between ACE2 and the SARS\u2010CoV\u20102 S protein is much higher than that of ACE2 binding to the SARS\u2010CoV S protein, explaining why SARS\u2010CoV\u20102 seems to be more readily transmitted from human to human. Here, we report that ACE2 can be significantly upregulated after infection of various viruses, including SARS\u2010CoV\u20101 and SARS\u2010CoV\u20102, or by the stimulation with inflammatory cytokines such as interferons. We propose that SARS\u2010CoV\u20102 may positively induce its cellular entry receptor, ACE2, to accelerate its replication and spread; high inflammatory cytokine levels increase ACE2 expression and act as high\u2010risk factors for developing COVID\u201019, and the infection of other viruses may increase the risk of SARS\u2010CoV\u20102 infection. Therefore, drugs targeting ACE2 may be developed for the future emerging infectious diseases caused by this cluster of coronaviruses.<\/jats:p>","DOI":"10.1002\/jmv.26139","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T13:26:12Z","timestamp":1591277172000},"page":"2693-2701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Increasing host cellular receptor\u2014angiotensin\u2010converting enzyme 2 expression by coronavirus may facilitate 2019\u2010nCoV (or SARS\u2010CoV\u20102) infection"],"prefix":"10.1002","volume":"92","author":[{"given":"Meng\u2010Wei","family":"Zhuang","sequence":"first","affiliation":[{"name":"Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Hong Kong Pokfulam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Advanced Medical Research Institute, Cheeloo College of Medicine Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Mei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jinan Infectious Diseases Hospital, Cheeloo College of Medicine Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinan Infectious Diseases Hospital, Cheeloo College of Medicine Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Hong Kong Pokfulam Hong 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