{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:00Z","timestamp":1740104100799,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As compared to many other viral pulmonary infections, there existed several peculiar manifestations in the COVID\u201019 patients, including the \u201csilence\u201d of pneumonia in both mild and severe cases and a long intensive care unit stay for those requiring invasive mechanical ventilation. Similar silent pneumonia has been documented in the infectioninduced by H5N1 influenza virus HK483 and was found to result from the direct attack of the virus on the bronchopulmonary C\u2010fibers at the early stage and the final infection in the brainstem at the late stage. The long stay of critical patients in the intensive care unit is possibly due to the depression of central respiratory drive, which resulted in the failure to wean from the mechanic ventilation. Carotid and aortic bodies and bronchopulmonary C\u2010fibers are two key peripheral components responsible for the chemosensitive responses in the respiratory system, while triggering respiratory reflexes depends predominantly on the putative chemosensitive neurons located in the pontomedullary nuclei. In view of the findings for the H5N1 influenza virus, the silence of pneumonia induced by SARS\u2010CoV\u20102 may be due to the possible impairment of peripheral chemosensitive reflexes as well as the damage to the respiratory\u2010related central neurons.<\/jats:p>","DOI":"10.1002\/jmv.26158","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T15:07:26Z","timestamp":1591888046000},"page":"2269-2271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The possible impairment of respiratory\u2010related neural loops may be associated with the silent pneumonia induced by SARS\u2010CoV\u20102"],"prefix":"10.1002","volume":"92","author":[{"given":"Bai\u2010Hong","family":"Tan","sequence":"first","affiliation":[{"name":"Laboratory Teaching Center of Basic Medicine Norman Bethune Health Science Center of Jilin University  Changchun Jilin 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